SCOPe 2.08: Structural Classification of Proteins

PDB entry 4pes

View 4pes on RCSB PDB site
Description: crystal structure of insulin degrading enzyme complexed with inhibitor tert-butyl [(2s)-2-(2,5-difluorophenyl)-3-(quinolin-3-yl) propyl]carbamate
Deposited on 2014-04-24, released 2015-06-17
The last revision was dated 2015-06-17, with a file datestamp of 2015-06-12.
Experiment type: XRAY
Resolution: 2.21 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Insulin-degrading enzyme
Species: Homo sapiens [TaxId:9606]
Gene: IDE
Database cross-references and differences (RAF-indexed):
- Uniprot P14735
  - engineered mutation (79-80)
  - engineered mutation (140)
  - engineered mutation (147)
  - engineered mutation (226)
  - engineered mutation (383)
  - engineered mutation (542)
  - engineered mutation (559)
  - engineered mutation (758)
  - engineered mutation (781)
  - engineered mutation (788)
  - engineered mutation (873)
Chain 'B':
Compound: Insulin-degrading enzyme
Species: Homo sapiens [TaxId:9606]
Gene: IDE
Database cross-references and differences (RAF-indexed):
- Uniprot P14735
  - engineered mutation (79-80)
  - engineered mutation (140)
  - engineered mutation (147)
  - engineered mutation (226)
  - engineered mutation (383)
  - engineered mutation (542)
  - engineered mutation (559)
  - engineered mutation (758)
  - engineered mutation (781)
  - engineered mutation (788)
  - engineered mutation (873)
Chain 'C':
Compound: ala-ala-ala
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 4PES (0-2)
Chain 'D':
Compound: ala-ala-ala
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 4PES (0-2)
Heterogens: 2PJ, ZN, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

Chain 'A':
Sequence, based on SEQRES records:

>4pesA (A:)
mghhhhhhgramnnpaikrignhitkspedkreyrglelangikvllisdpttdkssaal
dvhigslsdppniaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyy
fdvshehlegaldrfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgn
pkhpfskfgtgnkytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnl
vvklfsevenknvplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnp
ghylghlighegpgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvedi
ilhmfqyiqklraegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevl
taeylleefrpdliemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevi
kkwqnadlngkfklptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflp
kanlnfeffspfayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmyls
vkgyndkqpillkkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllm
tevawtkdelkealddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtli
ehahtkpllpsqlvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflel
faqiisepafntlrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitm
eksiedmteeafqkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylkt
ltkediikfykemlavdaprrhkvsvhvlaremdsnpvvgefpaqndinlsqapalpqpe
viqnmtefkrglplfplvkphinfmaakl

Sequence, based on observed residues (ATOM records):

>4pesA (A:)
npaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppni
aglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegald
rfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgnk
ytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenknv
plpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghlighegp
gsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklra
egpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpdl
iemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkfk
lptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspfa
yvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpillk
kiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelkea
lddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsql
vryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafntl
rtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeafq
khiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfykem
lavdaprrhkvsvhvlaremdslsqapalpqpeviqnmtefkrglplfplvkphi

Chain 'B':
Sequence, based on SEQRES records:

>4pesB (B:)
mghhhhhhgramnnpaikrignhitkspedkreyrglelangikvllisdpttdkssaal
dvhigslsdppniaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyy
fdvshehlegaldrfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgn
pkhpfskfgtgnkytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnl
vvklfsevenknvplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnp
ghylghlighegpgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvedi
ilhmfqyiqklraegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevl
taeylleefrpdliemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevi
kkwqnadlngkfklptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflp
kanlnfeffspfayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmyls
vkgyndkqpillkkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllm
tevawtkdelkealddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtli
ehahtkpllpsqlvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflel
faqiisepafntlrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitm
eksiedmteeafqkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylkt
ltkediikfykemlavdaprrhkvsvhvlaremdsnpvvgefpaqndinlsqapalpqpe
viqnmtefkrglplfplvkphinfmaakl

Sequence, based on observed residues (ATOM records):

>4pesB (B:)
nnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppn
iaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegal
drfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgn
kytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenkn
vplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghligheg
pgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklr
aegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpd
liemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkf
klptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspf
ayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpill
kkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelke
alddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsq
lvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafnt
lrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeaf
qkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyke
mlavdaprrhkvsvhvlaremdsdinlsqapalpqpeviqnmtefkrglplfplvkphi

Chain 'C':
Sequence; same for both SEQRES and ATOM records:
```
>4pesC (C:)
aaa
```
Chain 'D':
Sequence; same for both SEQRES and ATOM records:
```
>4pesD (D:)
aaa
```