PDB entry 4p90

View 4p90 on RCSB PDB site
Description: Crystal structure of the kinase domain of human PAK1 in complex with compound 15
Class: Transferase/Transferase inhibitor
Keywords: Inhibitor, kinase, Transferase-Transferase inhibitor complex
Deposited on 2014-04-01, released 2014-09-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-12-24, with a file datestamp of 2014-12-19.
Experiment type: XRAY
Resolution: 2.49 Å
R-factor: 0.209
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase PAK 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PAK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13153
      • engineered mutation (140)
      • engineered mutation (174)
      • engineered mutation (254)
    Domains in SCOPe 2.08: d4p90a_
  • Chain 'B':
    Compound: Serine/threonine-protein kinase PAK 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PAK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13153
      • engineered mutation (140)
      • engineered mutation (174)
      • engineered mutation (254)
    Domains in SCOPe 2.08: d4p90b_
  • Heterogens: 2K0, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4p90A (A:)
sdeeileklrsivsvgdpkkkytrfekigqgasgtvytamdvatgqevaikqmnlqqqpk
keliineilvmrenknpnivnyldsylvgdelwvvmeylaggsltdvvtetcmdegqiaa
vcreclqaleflhsnqvihrniksdnillgmdgsvkltdfgfcaqitpeqskrsemvgtp
ywmapevvtrkaygpkvdiwslgimaiemiegeppylnenplralyliatngtpelqnpe
klsaifrdflnrcldmdvekrgsakellqhqflkiakplssltpliaaakeatknnh

    Sequence, based on observed residues (ATOM records): (download) 
    >4p90A (A:)
deeileklrsivsvgdpkkkytrfekigqgasgtvytamevaikqmkeliineilvmren
knpnivnyldsylelwvvmeylaggsltdvvtetcmdegqiaavcreclqaleflhsnqv
ihrniksdnillgmdgsvkltdfgfcaqikrsemvgtpywmapevvtrkaygpkvdiwsl
gimaiemiegeppylnenplralyliatngtpelqnpeklsaifrdflnrcldmdvekrg
sakellqhqflkiakplssltpliaaakeatk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4p90B (B:)
sdeeileklrsivsvgdpkkkytrfekigqgasgtvytamdvatgqevaikqmnlqqqpk
keliineilvmrenknpnivnyldsylvgdelwvvmeylaggsltdvvtetcmdegqiaa
vcreclqaleflhsnqvihrniksdnillgmdgsvkltdfgfcaqitpeqskrsemvgtp
ywmapevvtrkaygpkvdiwslgimaiemiegeppylnenplralyliatngtpelqnpe
klsaifrdflnrcldmdvekrgsakellqhqflkiakplssltpliaaakeatknnh

    Sequence, based on observed residues (ATOM records): (download) 
    >4p90B (B:)
lrsivsvgdpkkkytrfekiggtvytamdvatgqevaikqmnlineilvmrenknpnivn
yldsylvgdelwvvmeylaggsltdvvtetcmdegqiaavcreclqaleflhsnqvihrn
iksdnillgmdgsvkltdskrsemvgtpywmapevvtrkaygpkvdiwslgimaiemieg
eppylnenplralyliatngtpelqnpeklsaifrdflnrcldmdvekrgsakellqhqf
lkiakplssltpliaaakeatk