PDB entry 4p7e

View 4p7e on RCSB PDB site
Description: Triazolopyridine compounds as selective JAK1 inhibitors: from hit identification to GLPG0634
Class: transferase
Keywords: Transferase, JAK1 inhibitor, Triazolopyridine
Deposited on 2014-03-27, released 2014-11-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-08-21, with a file datestamp of 2019-08-16.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674 (Start-292)
      • engineered mutation (289)
    Domains in SCOPe 2.08: d4p7ea_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674 (0-292)
      • engineered mutation (289)
    Domains in SCOPe 2.08: d4p7eb_
  • Heterogens: 2HB, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4p7eA (A:)
dptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdferei
eilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsq
ickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespif
wyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhli
ellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdqmag

    Sequence, based on observed residues (ATOM records): (download) 
    >4p7eA (A:)
qfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereieil
kslqhdnivkykgvcysnlklimeylpygslrdylqkhkeridhikllqytsqickgmey
lgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwyapesl
teskfsvasdvwsfgvvlyelftyieksksppaefmrmigngqmivfhliellknngrlp
rpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdqmag

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4p7eB (B:)
dptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdferei
eilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsq
ickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespif
wyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhli
ellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdqmag

    Sequence, based on observed residues (ATOM records): (download) 
    >4p7eB (B:)
dptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdferei
eilkslqhdnivkykgvcysnlklimeylpygslrdylqkhkeridhikllqytsqickg
meylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwyap
eslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqmivfhliellknn
grlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdqmag