PDB entry 4p6z

View 4p6z on RCSB PDB site
Description: Crystal structure of the human BST2 cytoplasmic domain and the HIV-1 Vpu cytoplasmic domain bound to the clathrin adaptor protein complex 1 (AP1) core
Class: protein transport
Keywords: BST2, tetherin, Vpu, HIV, clathrin, AP1, antiviral, restriction factor, antagonism, PROTEIN TRANSPORT
Deposited on 2014-03-25, released 2014-05-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: AP-1 complex subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: AP1B1, ADTB1, BAM22, CLAPB2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q10567
      • engineered mutation (446)
      • engineered mutation (491)
    Domains in SCOPe 2.08: d4p6zb_
  • Chain 'G':
    Compound: ap-1 complex subunit gamma-1
    Species: Mus musculus [TaxId:10090]
    Gene: Ap1g1, Adtg, Clapg1
    Database cross-references and differences (RAF-indexed):
  • Chain 'M':
    Compound: AP-1 complex subunit mu-1
    Species: Mus musculus [TaxId:10090]
    Gene: Ap1m1, Cltnm
    Database cross-references and differences (RAF-indexed):
  • Chain 'S':
    Compound: AP-1 complex subunit sigma-1A
    Species: Homo sapiens [TaxId:9606]
    Gene: AP1S1, AP19, CLAPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61966 (0-End)
      • engineered mutation (10)
    Domains in SCOPe 2.08: d4p6zs_
  • Chain 'T':
    Compound: Bone marrow stromal antigen 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BST2
    Database cross-references and differences (RAF-indexed):
  • Chain 'V':
    Compound: Protein Vpu
    Species: Human immunodeficiency virus type 1 group M subtype B [TaxId:11691]
    Gene: VPU
    Database cross-references and differences (RAF-indexed):
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4p6zB (B:)
mgsshhhhhhsqdpnsmtdskyftttkkgeifelkaelnsdkkekkkeavkkviasmtvg
kdvsalfpdvvncmqtdnlelkklvylylmnyaksqpdmaimavntfvkdcedpnplira
lavrtmgcirvdkiteylceplrkclkdedpyvrktaavcvaklhdinaqlvedqgfldt
lkdlisdsnpmvvanavaalseiaeshpssnlldlnpqsinklltalnectewgqifild
clanympkddreaqsicervtprlshansavvlsavkvlmkfmemlskdldyygtllkkl
applvtllsaepelqyvalrninlivqkrpeilkhemkvffvkyndpiyvklekldimir
lasqaniaqvlaelkeyatevdvdfvrkavraigrcaikveqsaercvstlldliqtkvn
yvvqeaivvikdifrkypnkyesviaalcenldsldepearaamiwivgeyaeridnade
llesflegfhdkstqvqlqlltaivklflkkptetqelvqqvlslatqdsdnpdlrdrgy
iywrllstdpvaakevvlaekpliseetdlieptlldelicyigtlasvyhkppsafveg

    Sequence, based on observed residues (ATOM records): (download) 
    >4p6zB (B:)
eifelkaelnsdkkekkkeavkkviasmtvgkdvsalfpdvvncmqtdnlelkklvylyl
mnyaksqpdmaimavntfvkdcedpnpliralavrtmgcirvdkiteylceplrkclkde
dpyvrktaavcvaklhdinaqlvedqgfldtlkdlisdsnpmvvanavaalseiaeshps
snlldlnpqsinklltalnectewgqifildclanympkddreaqsicervtprlshans
avvlsavkvlmkfmemlskdldyygtllkklapplvtllsaepelqyvalrninlivqkr
peilkhemkvffvkyndpiyvklekldimirlasqaniaqvlaelkeyatevdvdfvrka
vraigrcaikveqsaercvstlldliqtkvnyvvqeaivvikdifrkypnkyesviaalc
enldsldepearaamiwivgeyaeridnadellesflegfhdkstqvqlqlltaivklfl
kkptetqelvqqvlslatqdsdnpdlrdrgyiywrllstdpvaakevvlaekpliseetd
lieptlldelicyigtlasvyhkppsafve

  • Chain 'G':
    No sequence available.

  • Chain 'M':
    No sequence available.

  • Chain 'S':
    Sequence, based on SEQRES records: (download) 
    >4p6zS (S:)
mmrfmllfsrrgklrlqkwylatsdkerkkmvrelmqvvlarkpkmcsflewrdlkvvyk
ryaslyfccaiegqdnelitlelihryvelldkyfgsvceldiifnfekayfildeflmg
gdvqdtskksvlkaieqadllqeedesprsvleemgla

    Sequence, based on observed residues (ATOM records): (download) 
    >4p6zS (S:)
mmrfmllfsrrgklrlqkwylatsdkerkkmvrelmqvvlarkpkmcsflewrdlkvvyk
ryaslyfccaiegqdnelitlelihryvelldkyfgsvceldiifnfekayfildeflmg
gdvqdtskksvlkaieqadllqeedes

  • Chain 'T':
    No sequence available.

  • Chain 'V':
    No sequence available.