SCOPe 2.08: Structural Classification of Proteins

PDB entry 4p6x

View 4p6x on RCSB PDB site
Description: crystal structure of cortisol-bound glucocorticoid receptor ligand binding domain
Deposited on 2014-03-25, released 2014-04-16
The last revision was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Glucocorticoid receptor
Species: Homo sapiens [TaxId:9606]
Gene: NR3C1, GRL
Database cross-references and differences (RAF-indexed):
- Uniprot P04150 (Start-254)
  - engineered mutation (79)
  - engineered mutation (99)
  - engineered mutation (145)
  - engineered mutation (151-152)
  - engineered mutation (161)
  - engineered mutation (165)
Chain 'B':
Compound: nuclear receptor coactivator 2
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q15596 (Start-13)
Chain 'C':
Compound: Glucocorticoid receptor
Species: Homo sapiens [TaxId:9606]
Gene: NR3C1, GRL
Database cross-references and differences (RAF-indexed):
- Uniprot P04150 (0-254)
  - engineered mutation (79)
  - engineered mutation (99)
  - engineered mutation (145)
  - engineered mutation (151-152)
  - engineered mutation (161)
  - engineered mutation (165)
Chain 'D':
Compound: nuclear receptor coactivator 2
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q15596 (0-13)
Chain 'E':
Compound: Glucocorticoid receptor
Species: Homo sapiens [TaxId:9606]
Gene: NR3C1, GRL
Database cross-references and differences (RAF-indexed):
- Uniprot P04150 (0-254)
  - engineered mutation (79)
  - engineered mutation (99)
  - engineered mutation (145)
  - engineered mutation (151-152)
  - engineered mutation (161)
  - engineered mutation (165)
Chain 'F':
Compound: nuclear receptor coactivator 2
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q15596 (0-13)
Chain 'G':
Compound: Glucocorticoid receptor
Species: Homo sapiens [TaxId:9606]
Gene: NR3C1, GRL
Database cross-references and differences (RAF-indexed):
- Uniprot P04150 (0-End)
  - engineered mutation (79)
  - engineered mutation (99)
  - engineered mutation (145)
  - engineered mutation (151-152)
  - engineered mutation (161)
  - engineered mutation (165)
Chain 'H':
Compound: nuclear receptor coactivator 2
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q15596 (Start-13)
Chain 'I':
Compound: Glucocorticoid receptor
Species: Homo sapiens [TaxId:9606]
Gene: NR3C1, GRL
Database cross-references and differences (RAF-indexed):
- Uniprot P04150 (0-254)
  - engineered mutation (79)
  - engineered mutation (99)
  - engineered mutation (145)
  - engineered mutation (151-152)
  - engineered mutation (161)
  - engineered mutation (165)
Chain 'J':
Compound: nuclear receptor coactivator 2
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q15596 (Start-13)
Chain 'K':
Compound: Glucocorticoid receptor
Species: Homo sapiens [TaxId:9606]
Gene: NR3C1, GRL
Database cross-references and differences (RAF-indexed):
- Uniprot P04150 (0-254)
  - engineered mutation (79)
  - engineered mutation (99)
  - engineered mutation (145)
  - engineered mutation (151-152)
  - engineered mutation (161)
  - engineered mutation (165)
Chain 'L':
Compound: nuclear receptor coactivator 2
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q15596 (0-13)
Heterogens: HCY, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

Chain 'A':
Sequence, based on SEQRES records:

>4p6xA (A:)
atlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwakaip
gfrnlhlddqmtllqyswmalmafalgwrsyrqssanllyfapdliineqrmtlpcmydq
ckhmlyvsselhrlqvsyeeylcmkvllllstipkdglksqalfdairmtyikelgkaiv
kregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqip
kysngnikkllfhqk

Sequence, based on observed residues (ATOM records):

>4p6xA (A:)
pqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwakaipgfr
nlhlddqmtllqyswmalmafalgwrsyrqssanllyfapdliineqrmtlpcmydqckh
mlyvsselhrlqvsyeeylcmkvllllstipkdglksqalfdairmtyikelgkaivkre
gnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqipkys
ngnikkllfhqk

Chain 'B':
Sequence, based on SEQRES records:
```
>4p6xB (B:)
kenallrylldkdd
```
Sequence, based on observed residues (ATOM records):
```
>4p6xB (B:)
nallrylldkdd
```

Chain 'C':
Sequence; same for both SEQRES and ATOM records:

>4p6xC (C:)
atlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwakaip
gfrnlhlddqmtllqyswmalmafalgwrsyrqssanllyfapdliineqrmtlpcmydq
ckhmlyvsselhrlqvsyeeylcmkvllllstipkdglksqalfdairmtyikelgkaiv
kregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqip
kysngnikkllfhqk

Chain 'D':
Sequence; same for both SEQRES and ATOM records:
```
>4p6xD (D:)
kenallrylldkdd
```

Chain 'E':
Sequence; same for both SEQRES and ATOM records:

>4p6xE (E:)
atlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwakaip
gfrnlhlddqmtllqyswmalmafalgwrsyrqssanllyfapdliineqrmtlpcmydq
ckhmlyvsselhrlqvsyeeylcmkvllllstipkdglksqalfdairmtyikelgkaiv
kregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqip
kysngnikkllfhqk

Chain 'F':
Sequence; same for both SEQRES and ATOM records:
```
>4p6xF (F:)
kenallrylldkdd
```

Chain 'G':
Sequence, based on SEQRES records:

>4p6xG (G:)
atlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwakaip
gfrnlhlddqmtllqyswmalmafalgwrsyrqssanllyfapdliineqrmtlpcmydq
ckhmlyvsselhrlqvsyeeylcmkvllllstipkdglksqalfdairmtyikelgkaiv
kregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqip
kysngnikkllfhqk

Sequence, based on observed residues (ATOM records):

>4p6xG (G:)
atlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwakaip
gfrnlhlddqmtllqyswmalmafalgwrsyrqssanllyfapdliineqrmtlpcmydq
ckhmlyvsselhrlqvsyeeylcmkvllllstipkdglksqalfdairmtyikelgkaiv
kregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqip
kysngnikkllfhq

Chain 'H':
Sequence, based on SEQRES records:
```
>4p6xH (H:)
kenallrylldkdd
```
Sequence, based on observed residues (ATOM records):
```
>4p6xH (H:)
enallrylldkdd
```

Chain 'I':
Sequence; same for both SEQRES and ATOM records:

>4p6xI (I:)
atlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwakaip
gfrnlhlddqmtllqyswmalmafalgwrsyrqssanllyfapdliineqrmtlpcmydq
ckhmlyvsselhrlqvsyeeylcmkvllllstipkdglksqalfdairmtyikelgkaiv
kregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqip
kysngnikkllfhqk

Chain 'J':
Sequence, based on SEQRES records:
```
>4p6xJ (J:)
kenallrylldkdd
```
Sequence, based on observed residues (ATOM records):
```
>4p6xJ (J:)
nallrylldkdd
```

Chain 'K':
Sequence; same for both SEQRES and ATOM records:

>4p6xK (K:)
atlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwakaip
gfrnlhlddqmtllqyswmalmafalgwrsyrqssanllyfapdliineqrmtlpcmydq
ckhmlyvsselhrlqvsyeeylcmkvllllstipkdglksqalfdairmtyikelgkaiv
kregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqip
kysngnikkllfhqk

Chain 'L':
Sequence; same for both SEQRES and ATOM records:
```
>4p6xL (L:)
kenallrylldkdd
```