PDB entry 4p3o

View 4p3o on RCSB PDB site
Description: Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 2
Class: ligase/ligase inhibitor
Keywords: synthetase, inhibitor, LIGASE-LIGASE INHIBITOR complex
Deposited on 2014-03-09, released 2015-03-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2.51 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Threonine--tRNA ligase
    Species: Escherichia coli [TaxId:562]
    Gene: thrS, b1719, JW1709
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4p3oa1, d4p3oa2
  • Chain 'B':
    Compound: Threonine--tRNA ligase
    Species: Escherichia coli [TaxId:562]
    Gene: thrS, b1719, JW1709
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4p3ob1, d4p3ob2
  • Heterogens: ZN, 2CR, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4p3oA (A:)
mrdhrkigkqldlyhmqeeapgmvfwhndgwtifrelevfvrsklkeyqyqevkgpfmmd
rvlwektghwdnykdamfttssenreycikpmncpghvqifnqglksyrdlplrmaefgs
chrnepsgslhglmrvrgftqddahifcteeqirdevngcirlvydmystfgfekivvkl
strpekrigsdemwdraeadlavaleennipfeyqlgegafygpkieftlydcldrawqc
gtvqldfslpsrlsasyvgednerkvpvmihrailgsmerfigilteefagffptwlapv
qvvimnitdsqseyvneltqklsnagirvkadlrnekigfkirehtlrrvpymlvcgdke
vesgkvavrtrrgkdlgsmdvnevieklqqeirsrslkqleelehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4p3oA (A:)
rdhrkigkqldlyhmqeeapgmvfwhndgwtifrelevfvrsklkeyqyqevkgpfmmdr
vlwektghwdnykdamfttssenreycikpmncpghvqifnqglksyrdlplrmaefgsc
hrnepsgslhglmrvrgftqddahifcteeqirdevngcirlvydmystfgfekivvkls
trpekrigsdemwdraeadlavaleennipfeyqlgegafygpkieftlydcldrawqcg
tvqldfslpsrlsasyvgednerkvpvmihrailgsmerfigilteefagffptwlapvq
vvimnitdsqseyvneltqklsnagirvkadlrnekigfkirehtlrrvpymlvcgdkev
esgkvavrtrrgkdlgsmdvnevieklqqeirsrslkqlee

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4p3oB (B:)
mrdhrkigkqldlyhmqeeapgmvfwhndgwtifrelevfvrsklkeyqyqevkgpfmmd
rvlwektghwdnykdamfttssenreycikpmncpghvqifnqglksyrdlplrmaefgs
chrnepsgslhglmrvrgftqddahifcteeqirdevngcirlvydmystfgfekivvkl
strpekrigsdemwdraeadlavaleennipfeyqlgegafygpkieftlydcldrawqc
gtvqldfslpsrlsasyvgednerkvpvmihrailgsmerfigilteefagffptwlapv
qvvimnitdsqseyvneltqklsnagirvkadlrnekigfkirehtlrrvpymlvcgdke
vesgkvavrtrrgkdlgsmdvnevieklqqeirsrslkqleelehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4p3oB (B:)
rdhrkigkqldlyhmqeeapgmvfwhndgwtifrelevfvrsklkeyqyqevkgpfmmdr
vlwektghwdnykdamfttssenreycikpmncpghvqifnqglksyrdlplrmaefgsc
hrnepsgslhglmrvrgftqddahifcteeqirdevngcirlvydmystfgfekivvkls
trpekrigsdemwdraeadlavaleennipfeyqlgegafygpkieftlydcldrawqcg
tvqldfslpsrlsasyvgednerkvpvmihrailgsmerfigilteefagffptwlapvq
vvimnitdsqseyvneltqklsnagirvkadlrnekigfkirehtlrrvpymlvcgdkev
esgkvavrtrrgkdlgsmdvnevieklqqeirsrslkqlee