PDB entry 4p39

View 4p39 on RCSB PDB site
Description: Crystal structure of the human C5aR antagonist C5a-A8
Class: immune system
Keywords: complement anaphylatoxin, C5a, three-helix bundle, GPCR antagonist, IMMUNE SYSTEM
Deposited on 2014-03-06, released 2014-06-11
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-06-25, with a file datestamp of 2014-06-20.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.225
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Complement C5
    Species: Homo sapiens [TaxId:9606]
    Gene: C5, CPAMD4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01031 (7-End)
      • expression tag (6)
      • engineered mutation (33)
      • engineered mutation (73)
    Domains in SCOPe 2.04: d4p39a_
  • Chain 'B':
    Compound: Complement C5
    Species: Homo sapiens [TaxId:9606]
    Gene: C5, CPAMD4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01031 (7-End)
      • expression tag (6)
      • engineered mutation (33)
      • engineered mutation (73)
  • Chain 'C':
    Compound: Complement C5
    Species: Homo sapiens [TaxId:9606]
    Gene: C5, CPAMD4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01031 (7-End)
      • engineered mutation (33)
      • engineered mutation (73)
      • engineered mutation (75)
  • Chain 'D':
    Compound: Complement C5
    Species: Homo sapiens [TaxId:9606]
    Gene: C5, CPAMD4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01031 (7-End)
      • engineered mutation (33)
      • engineered mutation (73)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4p39A (A:)
gagaagstlqkkieeiaakykhsvvkkccydgarvnndetceqraarislgprcikafte
ccvvasqlranisfkrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4p39A (A:)
stlqkkieeiaakykhsvvkkccydgarvnndetceqraarislgprcikafteccvvas
qlranisfk

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.