PDB entry 4p38

View 4p38 on RCSB PDB site
Description: Human 11beta-Hydroxysteroid Dehydrogenase Type 1 in complex with AZD8329
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: Alpha Beta, Rossmann fold, NADP, Oxidoreductase-Oxidoreductase inhibitor complex
Deposited on 2014-03-06, released 2014-04-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HSD11B1, HSD11, HSD11L
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28845 (0-264)
      • conflict (153)
      • conflict (236)
      • conflict (246)
      • conflict (252)
      • conflict (260)
    Domains in SCOPe 2.08: d4p38a_
  • Chain 'B':
    Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HSD11B1, HSD11, HSD11L
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28845 (0-End)
      • conflict (153)
      • conflict (236)
      • conflict (246)
      • conflict (252)
      • conflict (260)
    Domains in SCOPe 2.08: d4p38b_
  • Heterogens: NDP, 21T, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4p38A (A:)
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvayplvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydssrwtt
llirnpsrkileelystsynwdrfi

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4p38B (B:)
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvayplvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydssrwtt
llirnpsrkileelystsynwdrfi

    Sequence, based on observed residues (ATOM records): (download) 
    >4p38B (B:)
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvayplvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsivhmqaapkeecaleiikggalrqeevyydssrwttl
lirnpsrkileelystsynwdrf