PDB entry 4p1x

View 4p1x on RCSB PDB site
Description: Crystal structure of staphylococcal LUK prepore
Class: toxin
Keywords: pore forming toxin, TOXIN
Deposited on 2014-02-28, released 2014-10-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-10-15, with a file datestamp of 2014-10-10.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.183
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Gamma-hemolysin component B
    Species: Staphylococcus aureus [TaxId:158878]
    Gene: hlgB, SAV2421
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q931F3 (Start-308)
      • engineered mutation (264)
    Domains in SCOPe 2.08: d4p1xa_
  • Chain 'B':
    Compound: Gamma-hemolysin component C
    Species: Staphylococcus aureus [TaxId:158878]
    Gene: hlgC, SAV2420
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4p1xb_
  • Chain 'C':
    Compound: Gamma-hemolysin component B
    Species: Staphylococcus aureus [TaxId:158878]
    Gene: hlgB, SAV2421
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q931F3 (Start-308)
      • engineered mutation (264)
    Domains in SCOPe 2.08: d4p1xc_
  • Chain 'D':
    Compound: Gamma-hemolysin component C
    Species: Staphylococcus aureus [TaxId:158878]
    Gene: hlgC, SAV2420
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4p1xd_
  • Chain 'E':
    Compound: Gamma-hemolysin component B
    Species: Staphylococcus aureus [TaxId:158878]
    Gene: hlgB, SAV2421
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q931F3 (Start-308)
      • engineered mutation (264)
    Domains in SCOPe 2.08: d4p1xe_
  • Chain 'F':
    Compound: Gamma-hemolysin component C
    Species: Staphylococcus aureus [TaxId:158878]
    Gene: hlgC, SAV2420
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4p1xf_
  • Chain 'G':
    Compound: Gamma-hemolysin component B
    Species: Staphylococcus aureus [TaxId:158878]
    Gene: hlgB, SAV2421
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q931F3 (Start-308)
      • engineered mutation (264)
    Domains in SCOPe 2.08: d4p1xg_
  • Chain 'H':
    Compound: Gamma-hemolysin component C
    Species: Staphylococcus aureus [TaxId:158878]
    Gene: hlgC, SAV2420
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4p1xh_
  • Heterogens: MPD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4p1xA (A:)
mghhhhhhamegkitpvsvkkvddkvtlykttatadsdkfkisqiltfnfikdksydkdt
lvlkatgninsgfvkpnpndydfsklywgakynvsissqsndsvnvvdyapknqneefqv
qntlgytfggdisisnglsgglngntafsetinykqesyrttlsrntnyknvgwgveahk
imnngwgpygrdsfhptygnelflagrqssayagqnfiaqhqmpllsrsnfnpeflsvls
hrqdgakkskitvtyqremdlyqirwngfywaganyknfktrtfkstyeidwenhkvkll
dtketennk

    Sequence, based on observed residues (ATOM records): (download) 
    >4p1xA (A:)
vtlykttatadsdkfkisqiltfnfikdksydkdtlvlkatgninsgfvkpnpndydfsk
lywgakynvsissqsndsvnvvdyapknqneefqvqntlgytfntafsetinykqesyrt
tlsrntnyknvgwgveahkimnngwgpygrdsfhptygnelflagrqssayagqnfiaqh
qmpllsrsnfnpeflsvlshrqdgakkskitvtyqremdlyqirwywaganyknfktrtf
kstyeidwenhkvklldtketennk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4p1xB (B:)
mghhhhhhamandtedigkgsdieiikrtedktsnkwgvtqniqfdfvkdkkynkdalil
kmqgfissrttyynykktnhvkamrwpfqyniglktndkyvslinylpknkiestnvsqt
lgyniggnfqsapslggngsfnysksisytqqnyvseveqqnsksvlwgvkansfatesg
qksafdsdlfvgykphskdprdyfvpdselpplvqsgfnpsfiatvshekgssdtsefei
tygrnmdvthaikrsthygnsyldghrvhnafvnrnytvkyevnwktheikvkgqn

    Sequence, based on observed residues (ATOM records): (download) 
    >4p1xB (B:)
dieiikrtedktsnkwgvtqniqfdfvkdkkynkdalilkmqgfissrttyynykktnhv
kamrwpfqyniglktndkyvslinylpknkiestnvsqtlgynisfnysksisytqqnyv
seveqqnsksvlwgvkansfatesgqksafdsdlfvgykphskdprdyfvpdselpplvq
sgfnpsfiatvshekgssdtsefeitygrnmdvthaikrsnsyldghrvhnafvnrnytv
kyevnwktheikvkgqn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4p1xC (C:)
mghhhhhhamegkitpvsvkkvddkvtlykttatadsdkfkisqiltfnfikdksydkdt
lvlkatgninsgfvkpnpndydfsklywgakynvsissqsndsvnvvdyapknqneefqv
qntlgytfggdisisnglsgglngntafsetinykqesyrttlsrntnyknvgwgveahk
imnngwgpygrdsfhptygnelflagrqssayagqnfiaqhqmpllsrsnfnpeflsvls
hrqdgakkskitvtyqremdlyqirwngfywaganyknfktrtfkstyeidwenhkvkll
dtketennk

    Sequence, based on observed residues (ATOM records): (download) 
    >4p1xC (C:)
vtlykttatadsdkfkisqiltfnfikdksydkdtlvlkatgninsgfvkpnpndydfsk
lywgakynvsissqsndsvnvvdyapknqneefqvqntlgytntafsetinykqesyrtt
lsrntnyknvgwgveahkimnngwgpygrdsfhptygnelflagrqssayagqnfiaqhq
mpllsrsnfnpeflsvlshrqdgakkskitvtyqremdlyqirwngfywaganyknfktr
tfkstyeidwenhkvklldtketennk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4p1xD (D:)
mghhhhhhamandtedigkgsdieiikrtedktsnkwgvtqniqfdfvkdkkynkdalil
kmqgfissrttyynykktnhvkamrwpfqyniglktndkyvslinylpknkiestnvsqt
lgyniggnfqsapslggngsfnysksisytqqnyvseveqqnsksvlwgvkansfatesg
qksafdsdlfvgykphskdprdyfvpdselpplvqsgfnpsfiatvshekgssdtsefei
tygrnmdvthaikrsthygnsyldghrvhnafvnrnytvkyevnwktheikvkgqn

    Sequence, based on observed residues (ATOM records): (download) 
    >4p1xD (D:)
dieiikrtedktsnkwgvtqniqfdfvkdkkynkdalilkmqgfissrttyynykktnhv
kamrwpfqyniglktndkyvslinylpknkiestnvsqtlgynisfnysksisytqqnyv
seveqqnsksvlwgvkansfatesgqksafdsdlfvgykphskdprdyfvpdselpplvq
sgfnpsfiatvshekgssdtsefeitygrnmdvthaikrsnsyldghrvhnafvnrnytv
kyevnwktheikvkgqn

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4p1xE (E:)
mghhhhhhamegkitpvsvkkvddkvtlykttatadsdkfkisqiltfnfikdksydkdt
lvlkatgninsgfvkpnpndydfsklywgakynvsissqsndsvnvvdyapknqneefqv
qntlgytfggdisisnglsgglngntafsetinykqesyrttlsrntnyknvgwgveahk
imnngwgpygrdsfhptygnelflagrqssayagqnfiaqhqmpllsrsnfnpeflsvls
hrqdgakkskitvtyqremdlyqirwngfywaganyknfktrtfkstyeidwenhkvkll
dtketennk

    Sequence, based on observed residues (ATOM records): (download) 
    >4p1xE (E:)
vtlykttatadsdkfkisqiltfnfikdksydkdtlvlkatgninsgfvkpnpndydfsk
lywgakynvsissqsndsvnvvdyapknqneefqvqntlgytntafsetinykqesyrtt
lsrntnyknvgwgveahkimnngwgpygrdsfhptygnelflagrqssayagqnfiaqhq
mpllsrsnfnpeflsvlshrqdgakkskitvtyqremdlyqirwngfywaganyknfktr
tfkstyeidwenhkvklldtketennk

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4p1xF (F:)
mghhhhhhamandtedigkgsdieiikrtedktsnkwgvtqniqfdfvkdkkynkdalil
kmqgfissrttyynykktnhvkamrwpfqyniglktndkyvslinylpknkiestnvsqt
lgyniggnfqsapslggngsfnysksisytqqnyvseveqqnsksvlwgvkansfatesg
qksafdsdlfvgykphskdprdyfvpdselpplvqsgfnpsfiatvshekgssdtsefei
tygrnmdvthaikrsthygnsyldghrvhnafvnrnytvkyevnwktheikvkgqn

    Sequence, based on observed residues (ATOM records): (download) 
    >4p1xF (F:)
dieiikrtedktsnkwgvtqniqfdfvkdkkynkdalilkmqgfissrttyynykktnhv
kamrwpfqyniglktndkyvslinylpknkiestnvsqtlgynigsfnysksisytqqny
vseveqqnsksvlwgvkansfatesgqksafdsdlfvgykpskdprdyfvpdselpplvq
sgfnpsfiatvshekgssdtsefeitygrnmdvthaikrsyldghrvhnafvnrnytvky
evnwktheikvkgqn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4p1xG (G:)
mghhhhhhamegkitpvsvkkvddkvtlykttatadsdkfkisqiltfnfikdksydkdt
lvlkatgninsgfvkpnpndydfsklywgakynvsissqsndsvnvvdyapknqneefqv
qntlgytfggdisisnglsgglngntafsetinykqesyrttlsrntnyknvgwgveahk
imnngwgpygrdsfhptygnelflagrqssayagqnfiaqhqmpllsrsnfnpeflsvls
hrqdgakkskitvtyqremdlyqirwngfywaganyknfktrtfkstyeidwenhkvkll
dtketennk

    Sequence, based on observed residues (ATOM records): (download) 
    >4p1xG (G:)
vtlykttatadsdkfkisqiltfnfikdksydkdtlvlkatgninsgfvkpnpndydfsk
lywgakynvsissqsndsvnvvdyapknqneefqvqntlgyttafsetinykqesyrttl
srntnyknvgwgveahkimnngwgpygrdsfhptygnelflagrqssayagqnfiaqhqm
pllsrsnfnpeflsvlshrqdgakkskitvtyqremdlyqirwngfywaganyknfktrt
fkstyeidwenhkvklldtketennk

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4p1xH (H:)
mghhhhhhamandtedigkgsdieiikrtedktsnkwgvtqniqfdfvkdkkynkdalil
kmqgfissrttyynykktnhvkamrwpfqyniglktndkyvslinylpknkiestnvsqt
lgyniggnfqsapslggngsfnysksisytqqnyvseveqqnsksvlwgvkansfatesg
qksafdsdlfvgykphskdprdyfvpdselpplvqsgfnpsfiatvshekgssdtsefei
tygrnmdvthaikrsthygnsyldghrvhnafvnrnytvkyevnwktheikvkgqn

    Sequence, based on observed residues (ATOM records): (download) 
    >4p1xH (H:)
dieiikrtedktsnkwgvtqniqfdfvkdkkynkdalilkmqgfissrttyynykktnhv
kamrwpfqyniglktndkyvslinylpknkiestnvsqtlgynisfnysksisytqqnyv
seveqqnsksvlwgvkansfatesgqksafdsdlfvgykphskdprdyfvpdselpplvq
sgfnpsfiatvshekgssdtsefeitygrnmdvthaikrsgnsyldghrvhnafvnrnyt
vkyevnwktheikvkgqn