PDB entry 4p0v

View 4p0v on RCSB PDB site
Description: Crystal structure of human farnesyl diphosphoate synthase in complex with zoledronate and taxodione
Class: transferase/transferase inhibitor
Keywords: Human, FPPS, Inhibitor, Complex, Synthase, transferase-transferase inhibitor complex
Deposited on 2014-02-21, released 2014-07-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: farnesyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDPS, FPS, KIAA1293
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4p0va_
  • Heterogens: ZOL, 1WO, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4p0vA (A:)
sdvyaqekqdfvqhfsqivrvltedemghpeigdaiarlkevleynaiggkynrgltvvv
afrelveprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgl
daindanlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlv
rftekryksivkyktafysfylpiaaamymagidgekehanakkillemgeffqiqddyl
dlfgdpsvtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalye
eldlpavflqyeedsyshimalieqyaaplppavflglarkiykrrk

    Sequence, based on observed residues (ATOM records): (download) 
    >4p0vA (A:)
dvyaqekqdfvqhfsqivrvltedemghpeigdaiarlkevleynaiggkynrgltvvva
frelveprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgld
aindanlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvr
ftekryksivkyktafysfylpiaaamymagidgekehanakkillemgeffqiqddyld
lfgdpsvtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyee
ldlpavflqyeedsyshimalieqyaaplppavflglarkiykrrk