PDB entry 4ow0
View 4ow0 on RCSB PDB site
Description: X-Ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases
Class: hydrolase/hydrolase inhibitor
Keywords: CoV, coronavirus, HCoV, human coronavirus, SARS, severe acute respiratory syndrome, MERS, Middle East respiratory syndrome, PLpro, papain-like protease; inhibitor, complex, DUB, deubiquitinating enzyme, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on
2014-01-28, released
2014-04-23
The last revision prior to the SCOPe 2.06 freeze date was dated
2014-04-30, with a file datestamp of
2014-04-25.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.178
AEROSPACI score: 0.35
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: papain-like protease
Species: SARS coronavirus [TaxId:228330]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4ow0a1, d4ow0a2 - Chain 'B':
Compound: papain-like protease
Species: SARS coronavirus [TaxId:228330]
Database cross-references and differences (RAF-indexed):
- Heterogens: ZN, S88, DMS, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4ow0A (A:)
mevktikvfttvdntnlhtqlvdmsmtygqqfgptyldgadvtkikphvnhegktffvlp
sddtlrseafeyyhtldesflgrymsalnhtkkwkfpqvggltsikwadnncylssvlla
lqqlevkfnapalqeayyraragdaanfcalilaysnktvgelgdvretmthllqhanle
sakrvlnvvckhcgqktttltgveavmymgtlsydnlktgvsipcvcgrdatqylvqqes
sfvmmsappaeyklqqgtflcaneytgnyqcghythitaketlyridgahltkmseykgp
vtdvfyketsytttik
Sequence, based on observed residues (ATOM records): (download)
>4ow0A (A:)
ktikvfttvdntnlhtqlvdmsmtygqqfgptyldgadvtkikphvnhegktffvlpsdd
tlrseafeyyhtldesflgrymsalnhtkkwkfpqvggltsikwadnncylssvllalqq
levkfnapalqeayyraragdaanfcalilaysnktvgelgdvretmthllqhanlesak
rvlnvvckhcgqktttltgveavmymgtlsydnlktgvsipcvcgrdatqylvqqessfv
mmsappaeyklqqgtflcaneytgnyqcghythitaketlyridgahltkmseykgpvtd
vfyketsyttti
- Chain 'B':
No sequence available.