PDB entry 4ovu

View 4ovu on RCSB PDB site
Description: crystal structure of p110alpha in complex with nish2 of p85alpha
Deposited on 2014-01-14, released 2014-09-03
The last revision was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 2.96 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P42336
      • expression tag (0-16)
  • Chain 'B':
    Compound: Phosphatidylinositol 3-kinase regulatory subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: GRB1,PI3KR1,PIK3R1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4ovuA (A:)
msyyhhhhhhdydipttenlyfqgamgsmpprpssgelwgihlmpprilvecllpngmiv
tleclreatlitikhelfkearkyplhqllqdessyifvsvtqeaereeffdetrrlcdl
rlfqpflkviepvgnreekilnreigfaigmpvcefdmvkdpevqdfrrnilnvckeavd
lrdlnsphsramyvyppnvesspelpkhiynkldkgqiivviwvivspnndkqkytlkin
hdcvpeqviaeairkktrsmllsseqlklcvleyqgkyilkvcgcdeyflekyplsqyky
irscimlgrmpnlmlmakeslysqlpmdcftmpsysrristatpymngetstkslwvins
alrikilcatyvnvnirdidkiyvrtgiyhggeplcdnvntqrvpcsnprwnewlnydiy
ipdlpraarlclsicsvkgrkgakeehcplawgninlfdytdtlvsgkmalnlwpvphgl
edllnpigvtgsnpnketpclelefdwfssvvkfpdmsvieehanwsvsreagfsyshag
lsnrlardnelrendkeqlkaistrdplseiteqekdflwshrhycvtipeilpklllsv
kwnsrdevaqmyclvkdwppikpeqamelldcnypdpmvrgfavrclekyltddklsqyl
iqlvqvlkyeqyldnllvrfllkkaltnqrighfffwhlksemhnktvsqrfglllesyc
racgmylkhlnrqveameklinltdilkqekkdetqkvqmkflveqmrrpdfmdalqgfl
splnpahqlgnlrleecrimssakrplwlnwenpdimsellfqnneiifkngddlrqdml
tlqiirimeniwqnqgldlrmlpygclsigdcvglievvrnshtimqiqckgglkgalqf
nshtlhqwlkdknkgeiydaaidlftrscagycvatfilgigdrhnsnimvkddgqlfhi
dfghfldhkkkkfgykrervpfvltqdfliviskgaqectktreferfqemcykaylair
qhanlfinlfsmmlgsgmpelqsfddiayirktlaldkteqealeyfmkqmndahhggwt
tkmdwifhtikqhaln

    Sequence, based on observed residues (ATOM records):
    >4ovuA (A:)
msyyhhhhhhdydipttssgelwgihlmpprilvecllpngmivtleclreatlitikhe
lfkearkyplhqllqdessyifvsvtqeaereeffdetrrlcdlrlfqpflkviepvgnr
eekilnreigfaigmpvcefdmvkdpevqdfrrnilnvckeavdlrdlnsphsramyvyp
pnvesspelpkhiynkldkgqiivviwvivspnndkqkytlkinhdcvpeqviaeairkk
trsmllsseqlklcvleyqgkyilkvcgcdeyflekyplsqykyirscimlgrmpnlmlm
akeslysqlpmdcftmpsysngetstkslwvinsalrikilcatyvnvnirdidkiyvrt
giyhggeplcdnvntqrvpcsnprwnewlnydiyipdlpraarlclsicsvkeehcplaw
gninlfdytdtlvsgkmalnlwpvphgledllnpigvtgsnpnketpclelefdwfssvv
kfpdmsvieehanwsvsreagfsyshaglsrdnelrendkeqlkaistrdplseiteqek
dflwshrhycvtipeilpklllsvkwnsrdevaqmyclvkdwppikpeqamelldcnypd
pmvrgfavrclekyltddklsqyliqlvqvlkyeqyldnllvrfllkkaltnqrighfff
whlksemhnktvsqrfglllesycracgmylkhlnrqveameklinltdilkqekkdetq
kvqmkflveqmrrpdfmdalqgflsplnpahqlgnlrleecrimssakrplwlnwenpdi
msellfqnneiifkngddlrqdmltlqiirimeniwqnqgldlrmlpygclsigdcvgli
evvrnshtimqiqckgglkgalqfnshtlhqwlkdknkgeiydaaidlftrscagycvat
filgigdrhnsnimvkddgqlfhidfghfldhkkkkfgykrervpfvltqdfliviskga
qectktreferfqemcykaylairqhanlfinlfsmmlgsgmpelqsfddiayirktlal
dkteqealeyfmkqmndahhggwt

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4ovuB (B:)
mnnnmslqdaewywgdisreevneklrdtadgtflvrdastkmhgdytltlrkggnnkli
kifhrdgkygfsdpltfssvvelinhyrneslaqynpkldvkllypvskyqqdqvvkedn
ieavgkklheyntqfqeksreydrlyeeytrtsqeiqmkrtaieafnetikifeeqcqtq
eryskeyiekfkregnekeiqrimhnydklksriseiidsrrrleedlkkqaaeyreidk
rmnsikpdliqlrktrdqylmwltqkgvrqkklnewlgn

    Sequence, based on observed residues (ATOM records):
    >4ovuB (B:)
slqdaewywgdisreevneklrdtadgtflvrdastkmhgdytltlrkggnnklikifhr
dgkygfsdpltfssvvelinhyrneslaqynpkldvkllypvskyqqdqvvkednieavg
kklheyntqfqeksreydrlyeeytrtsqeiqmkrtaieafnetikifeeqcqtqerysk
eyiekfnekeiqrimhnydklksriseiidsrrrleedlkkqaaeyreidkrmnsikpdl
iqlrktrdqylmwltqkgvrqkklnewl