PDB entry 4ov6

View 4ov6 on RCSB PDB site
Description: Crystal structure of PCSK9(53-451) with Adnectin
Class: hydrolase/protein binding
Keywords: PCSK9, Adnectin, LDL-cholesterol, HYDROLASE-PROTEIN BINDING complex
Deposited on 2014-02-20, released 2014-07-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.69 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1, PSEC0052
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1, PSEC0052
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4ov6b_
  • Chain 'D':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1, PSEC0052
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1, PSEC0052
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4ov6e_
  • Chain 'F':
    Compound: adnectin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4OV6 (0-98)
    Domains in SCOPe 2.08: d4ov6f_
  • Chain 'G':
    Compound: adnectin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4OV6 (0-End)
    Domains in SCOPe 2.08: d4ov6g_
  • Heterogens: EDO, PG4, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ov6B (B:)
sipwnleritppryradeyqppdggslvevylldtsiqsdhreiegrvmvtdfenvpeed
gtrfhrqaskcdshgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefir
ksqlvqpvgplvvllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasape
vitvgatnaqdqpvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahv
agiaammlsaepeltlaelrqrlihfsakdvineawfpedqrvltpnlvaalpp

    Sequence, based on observed residues (ATOM records): (download) 
    >4ov6B (B:)
sipwnleritppslvevylldtsiqsdhreiegrvmvtdfenvpeedgtrfhrqaskcds
hgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefirksqlvqpvgplvv
llplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasapevitvgatnaqdqp
vtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahvagiaammlsaepe
ltlaelrqrlihfsakdvineawfpedqrvltpnlvaalpp

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4ov6E (E:)
sipwnleritppryradeyqppdggslvevylldtsiqsdhreiegrvmvtdfenvpeed
gtrfhrqaskcdshgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefir
ksqlvqpvgplvvllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasape
vitvgatnaqdqpvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahv
agiaammlsaepeltlaelrqrlihfsakdvineawfpedqrvltpnlvaalpp

    Sequence, based on observed residues (ATOM records): (download) 
    >4ov6E (E:)
sipwnleritplvevylldtsiqsdhreiegrvmvtdfenvpeedskcdshgthlagvvs
grdagvakgasmrslrvlncqgkgtvsgtliglefirksqlvqpvgplvvllplaggysr
vlnaacqrlaragvvlvtaagnfrddaclyspasapevitvgatnaqdqpvtlgtlgtnf
grcvdlfapgediigassdcstcfvsqsgtsqaaahvagiaammlsaepeltlaelrqrl
ihfsakdvineawfpedqrvltpnlvaalp

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4ov6F (F:)
gvsdvprdlevvaatptslliswpppshgygyyritygetggnspvqeftvppgkgtati
sglkpgvdytitvyaveypykhsgyyhrpisinyrteid

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4ov6G (G:)
gvsdvprdlevvaatptslliswpppshgygyyritygetggnspvqeftvppgkgtati
sglkpgvdytitvyaveypykhsgyyhrpisinyrteid

    Sequence, based on observed residues (ATOM records): (download) 
    >4ov6G (G:)
gvsdvprdlevvaatptslliswpppshgygyyritygetggnspvqeftvppgkgtati
sglkpgvdytitvyaveypykhsgyyhrpisinyrt