PDB entry 4ov5

View 4ov5 on RCSB PDB site
Description: Structure of HLA-DR1 with a bound peptide with non-optimal alanine in the P1 pocket
Deposited on 2014-02-20, released 2014-07-16
The last revision was dated 2014-09-10, with a file datestamp of 2014-09-05.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.207
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA, HLA-DRA1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: HLA class II histocompatibility antigen, DRB1-1 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB, HLA-DRB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01892 (0-13)
      • engineered mutation (3)
      • engineered mutation (11)
  • Chain 'D':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA, HLA-DRA1
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: HLA class II histocompatibility antigen, DRB1-1 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB, HLA-DRB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01892 (0-13)
      • engineered mutation (3)
      • engineered mutation (11)
  • Chain 'G':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA, HLA-DRA1
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: HLA class II histocompatibility antigen, DRB1-1 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB, HLA-DRB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01892
      • engineered mutation (3)
      • engineered mutation (11)
  • Chain 'J':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA, HLA-DRA1
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: HLA class II histocompatibility antigen, DRB1-1 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB, HLA-DRB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01892 (0-13)
      • engineered mutation (3)
      • engineered mutation (11)
  • Chain 'M':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA, HLA-DRA1
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: HLA class II histocompatibility antigen, DRB1-1 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB, HLA-DRB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'O':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01892 (0-13)
      • engineered mutation (3)
      • engineered mutation (11)
  • Chain 'P':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA, HLA-DRA1
    Database cross-references and differences (RAF-indexed):
  • Chain 'Q':
    Compound: HLA class II histocompatibility antigen, DRB1-1 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB, HLA-DRB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'R':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01892 (0-13)
      • engineered mutation (3)
      • engineered mutation (11)
  • Heterogens: HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4ov5A (A:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
da

    Sequence, based on observed residues (ATOM records):
    >4ov5A (A:)
eehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalan
iavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwl
rngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefda

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4ov5B (B:)
gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvs
gfypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
tspltvewra

    Sequence, based on observed residues (ATOM records):
    >4ov5B (B:)
dtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaeyw
nsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvsg
fypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsvt
spltvewra

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >4ov5C (C:)
gsdarflrgyhlya

  • Chain 'D':
    Sequence, based on SEQRES records:
    >4ov5D (D:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
da

    Sequence, based on observed residues (ATOM records):
    >4ov5D (D:)
eehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalan
iavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwl
rngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefd

  • Chain 'E':
    Sequence, based on SEQRES records:
    >4ov5E (E:)
gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvs
gfypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
tspltvewra

    Sequence, based on observed residues (ATOM records):
    >4ov5E (E:)
dtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaeyw
nsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqhhnllvcsvsgfyp
gsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsvtspl
tvewra

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records:
    >4ov5F (F:)
gsdarflrgyhlya

  • Chain 'G':
    Sequence, based on SEQRES records:
    >4ov5G (G:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
da

    Sequence, based on observed residues (ATOM records):
    >4ov5G (G:)
eehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalan
iavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwl
rngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefd

  • Chain 'H':
    Sequence, based on SEQRES records:
    >4ov5H (H:)
gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvs
gfypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
tspltvewra

    Sequence, based on observed residues (ATOM records):
    >4ov5H (H:)
dtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaeyw
nsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvsg
fypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsvt
spltvewra

  • Chain 'I':
    Sequence, based on SEQRES records:
    >4ov5I (I:)
gsdarflrgyhlya

    Sequence, based on observed residues (ATOM records):
    >4ov5I (I:)
sdarflrgyhl

  • Chain 'J':
    Sequence, based on SEQRES records:
    >4ov5J (J:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
da

    Sequence, based on observed residues (ATOM records):
    >4ov5J (J:)
ehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalani
avdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwlr
ngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef

  • Chain 'K':
    Sequence, based on SEQRES records:
    >4ov5K (K:)
gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvs
gfypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
tspltvewra

    Sequence, based on observed residues (ATOM records):
    >4ov5K (K:)
gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqhhnllvcsvsgfy
pgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsvtsp
ltvewra

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records:
    >4ov5L (L:)
gsdarflrgyhlya

  • Chain 'M':
    Sequence, based on SEQRES records:
    >4ov5M (M:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
da

    Sequence, based on observed residues (ATOM records):
    >4ov5M (M:)
ehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalani
avdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwlr
ngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefda

  • Chain 'N':
    Sequence, based on SEQRES records:
    >4ov5N (N:)
gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvs
gfypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
tspltvewra

    Sequence, based on observed residues (ATOM records):
    >4ov5N (N:)
dtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaeyw
nsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypslqhhnllvcsvsgfypg
sievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsvtsplt
vewra

  • Chain 'O':
    Sequence; same for both SEQRES and ATOM records:
    >4ov5O (O:)
gsdarflrgyhlya

  • Chain 'P':
    Sequence, based on SEQRES records:
    >4ov5P (P:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
da

    Sequence, based on observed residues (ATOM records):
    >4ov5P (P:)
ehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalani
avdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwlr
ngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefda

  • Chain 'Q':
    Sequence, based on SEQRES records:
    >4ov5Q (Q:)
gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvs
gfypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
tspltvewra

    Sequence, based on observed residues (ATOM records):
    >4ov5Q (Q:)
dtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaeyw
nsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvsg
fypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsvt
spltvewra

  • Chain 'R':
    Sequence; same for both SEQRES and ATOM records:
    >4ov5R (R:)
gsdarflrgyhlya