PDB entry 4oti

View 4oti on RCSB PDB site
Description: Crystal Structure of PRK1 Catalytic Domain in Complex with Tofacitinib
Class: transferase/transferase inhibitor
Keywords: PRK1, PKN1, Protein kinase C related kinase 1, KINASE, PROTEIN KINASE, ATP BINDING, PHOSPHORYLATION, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2014-02-13, released 2014-08-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-24, with a file datestamp of 2018-01-19.
Experiment type: XRAY
Resolution: 1.93 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase N1
    Species: Homo sapiens [TaxId:9606]
    Gene: PKN1, PAK1, PKN, PRK1, PRKCL1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4otia_
  • Heterogens: MI1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4otiA (A:)
gsmlrkspltledfkflavlgrghfgkvllsefrpsgelfaikalkkgdivardeveslm
cekrilaavtsaghpflvnlfgcfqtpehvcfvmeysaggdlmlhihsdvfsepraifys
acvvlglqflhehkivyrdlkldnllldtegyvkiadfglckegmgygdrtstfcgtpef
lapevltdtsytravdwwglgvllyemlvgespfpgddeeevfdsivndevryprflsae
aigimrrllrrnperrlgsserdaedvkkqpffrtlgweallarrlpppfvptlsgrtdv
snfdeeftgeaptlspprdarpltaaeqaafldfdfvaggc

    Sequence, based on observed residues (ATOM records): (download) 
    >4otiA (A:)
rkspltledfkflavlgrghfgkvllsefrpsgelfaikalkkgdivardeveslmcekr
ilaavtsaghpflvnlfgcfqtpehvcfvmeysaggdlmlhihsdvfsepraifysacvv
lglqflhehkivyrdlkldnllldtegyvkiadfgltravdwwglgvllyemlvgespfp
gddeeevfdsivndevryprflsaeaigimrrllrrnperrlgsserdaedvkkqpffrt
lgweallarrlpppfvptlsgrtdvsnfdeeftgeaptlspprdarpltaaeqaafldfd
fvag