PDB entry 4otf

View 4otf on RCSB PDB site
Description: Crystal structure of the kinase domain of Bruton's Tyrosine kinase with GDC0834
Class: transferase/transferase inhibitor
Keywords: kinase, transferase-transferase inhibitor complex
Deposited on 2014-02-13, released 2015-01-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-04-01, with a file datestamp of 2015-03-27.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase BTK
    Species: Homo sapiens [TaxId:9606]
    Gene: AGMX1, ATK, BPK, BTK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06187 (Start-265)
      • expression tag (266)
    Domains in SCOPe 2.08: d4otfa1, d4otfa2
  • Heterogens: SO4, 2VL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4otfA (A:)
mgsweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmn
lsheklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceamey
leskqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmy
skfssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvytimy
scwhekaderptfkillsnildvmdenlygn

    Sequence, based on observed residues (ATOM records): (download) 
    >4otfA (A:)
eidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnlshe
klvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameylesk
qflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmyskfs
sksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvytimyscwh
ekaderptfkillsnildvmden