PDB entry 4or5
View 4or5 on RCSB PDB site
Description: Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4
Class: Transferase/Transcription
Keywords: Cdk9, Tat, AFF4, Zinc Finger, Transcription, RNA binding, Phosphorylation, Transferase-Transcription complex
Deposited on
2014-02-10, released
2014-04-16
The last revision prior to the SCOPe 2.06 freeze date was dated
2014-06-11, with a file datestamp of
2014-06-06.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.225
AEROSPACI score: 0.16
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cyclin-dependent kinase 9
Species: Homo sapiens [TaxId:9606]
Gene: CDK9, CDC2L4, TAK
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4or5a_ - Chain 'B':
Compound: Cyclin-T1
Species: Homo sapiens [TaxId:9606]
Gene: CCNT1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4or5b1, d4or5b2 - Chain 'C':
Compound: protein tat
Species: HIV-1 [TaxId:11706]
Gene: TAT
Database cross-references and differences (RAF-indexed):
- Chain 'E':
Compound: AF4/FMR2 family member 4
Species: Homo sapiens [TaxId:9606]
Gene: AFF4, AF5Q31, MCEF, HSPC092
Database cross-references and differences (RAF-indexed):
- Chain 'F':
Compound: Cyclin-dependent kinase 9
Species: Homo sapiens [TaxId:9606]
Gene: CDK9, CDC2L4, TAK
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4or5f_ - Chain 'G':
Compound: Cyclin-T1
Species: Homo sapiens [TaxId:9606]
Gene: CCNT1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4or5g1, d4or5g2 - Chain 'H':
Compound: protein tat
Species: HIV-1 [TaxId:11706]
Gene: TAT
Database cross-references and differences (RAF-indexed):
- Chain 'J':
Compound: AF4/FMR2 family member 4
Species: Homo sapiens [TaxId:9606]
Gene: AFF4, AF5Q31, MCEF, HSPC092
Database cross-references and differences (RAF-indexed):
- Heterogens: YT3, SO4, ZN, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4or5A (A:)
svecpfcdevskyeklakigqgtfgevfkarhrktgqkvalkkvlmenekegfpitalre
ikilqllkhenvvnlieicrtkaspynrckgsiylvfdfcehdlagllsnvlvkftlsei
krvmqmllnglyyihrnkilhrdmkaanvlitrdgvlkladfglarafslaknsqpnryt
nrvvtlwyrppelllgerdygppidlwgagcimaemwtrspimqgnteqhqlalisqlcg
sitpevwpnvdnyelyeklelvkgqkrkvkdrlkayvrdpyaldlidkllvldpaqrids
ddalnhdffwsdpmpsdlkgmlsthl
Sequence, based on observed residues (ATOM records): (download)
>4or5A (A:)
vecpfcdevskyeklakigqgtfgevfkarhrktgqkvalkkvlmenekegfpitalrei
kilqllkhenvvnlieicrtkaspkgsiylvfdfcehdlagllsnvlvkftlseikrvmq
mllnglyyihrnkilhrdmkaanvlitrdgvlkladfglarafslaknsqpnrytnrvvt
lwyrppelllgerdygppidlwgagcimaemwtrspimqgnteqhqlalisqlcgsitpe
vwpnvdnyelyeklelvkgqkrkvkdrlkayvrdpyaldlidkllvldpaqridsddaln
hdffwsdpmpsdlkgmlsth
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4or5B (B:)
megerknnnkrwyftreqlenspsrrfgvdpdkelsyrqqaanllqdmgqrlnvsqltin
taivymhrfymiqsftqfpgnsvapaalflaakveeqpkklehvikvahtclhpqeslpd
trseaylqqvqdlvilesiilqtlgfeltidhphthvvkctqlvraskdlaqtsyfmatn
slhlttfslqytppvvacvcihlackwsnweipvstdgkhwweyvdatvtlelldelthe
flqilektpnrlkriwnwraceaakk
Sequence, based on observed residues (ATOM records): (download)
>4or5B (B:)
nnnkrwyftreqlenspsrrfgvdpdkelsyrqqaanllqdmgqrlnvsqltintaivym
hrfymiqsftqfpgnsvapaalflaakveeqpkklehvikvahtclhpqeslpdtrseay
lqqvqdlvilesiilqtlgfeltidhphthvvkctqlvraskdlaqtsyfmatnslhltt
fslqytppvvacvcihlackwsnweipvstdgkhwweyvdatvtlelldeltheflqile
ktpnrlkriwnwrace
- Chain 'C':
No sequence available.
- Chain 'E':
No sequence available.
- Chain 'F':
Sequence, based on SEQRES records: (download)
>4or5F (F:)
svecpfcdevskyeklakigqgtfgevfkarhrktgqkvalkkvlmenekegfpitalre
ikilqllkhenvvnlieicrtkaspynrckgsiylvfdfcehdlagllsnvlvkftlsei
krvmqmllnglyyihrnkilhrdmkaanvlitrdgvlkladfglarafslaknsqpnryt
nrvvtlwyrppelllgerdygppidlwgagcimaemwtrspimqgnteqhqlalisqlcg
sitpevwpnvdnyelyeklelvkgqkrkvkdrlkayvrdpyaldlidkllvldpaqrids
ddalnhdffwsdpmpsdlkgmlsthl
Sequence, based on observed residues (ATOM records): (download)
>4or5F (F:)
vecpfcdevskyeklakigqgtfgevfkarhrktgqkvalkkvlmenekegfpitalrei
kilqllkhenvvnlieicrtkaspynrckgsiylvfdfcehdlagllsnvlvkftlseik
rvmqmllnglyyihrnkilhrdmkaanvlitrdgvlkladfglarafslaknsqpnrytn
rvvtlwyrppelllgerdygppidlwgagcimaemwtrspimqgnteqhqlalisqlcgs
itpevwpnvdnyelyeklelvkgqkrkvkdrlkayvrdpyaldlidkllvldpaqridsd
dalnhdffwsdpmpsdlkgmlsthl
- Chain 'G':
Sequence, based on SEQRES records: (download)
>4or5G (G:)
megerknnnkrwyftreqlenspsrrfgvdpdkelsyrqqaanllqdmgqrlnvsqltin
taivymhrfymiqsftqfpgnsvapaalflaakveeqpkklehvikvahtclhpqeslpd
trseaylqqvqdlvilesiilqtlgfeltidhphthvvkctqlvraskdlaqtsyfmatn
slhlttfslqytppvvacvcihlackwsnweipvstdgkhwweyvdatvtlelldelthe
flqilektpnrlkriwnwraceaakk
Sequence, based on observed residues (ATOM records): (download)
>4or5G (G:)
nnnkrwyftreqlenspsrrfgvdpdkelsyrqqaanllqdmgqrlnvsqltintaivym
hrfymiqsftqfpgnsvapaalflaakveeqpkklehvikvahtclhpqeslpdtrseay
lqqvqdlvilesiilqtlgfeltidhphthvvkctqlvraskdlaqtsyfmatnslhltt
fslqytppvvacvcihlackwsnweipvstdgkhwweyvdatvtlelldeltheflqile
ktpnrlkriwnwrac
- Chain 'H':
No sequence available.
- Chain 'J':
No sequence available.