PDB entry 4oqx

View 4oqx on RCSB PDB site
Description: Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with Me-ARA-EdU
Class: transferase
Keywords: DNA SYNTHESIS, Thymidine kinase, ATP-Binding, nucleotide-binding, TRANSFERASE, 5-ETHYNYLURIDINE NUCLEOSIDE DERIVATIVE
Deposited on 2014-02-10, released 2014-08-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidine kinase
    Species: Human herpesvirus 1 [TaxId:10299]
    Gene: TK, TK (UL23), UL23
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4oqxa_
  • Chain 'B':
    Compound: Thymidine kinase
    Species: Human herpesvirus 1 [TaxId:10299]
    Gene: TK, TK (UL23), UL23
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4oqxb_
  • Heterogens: SO4, EDV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4oqxA (A:)
kmptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianiyttq
hrldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeagsshapppaltlifdrh
piaallcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpg
erldlamlaairrvygllantvrylqcggswredwgqlsgtavppqgaepqsnagprphi
gdtlftlfrapellapngdlynvfawaldvlakrlrsmhvfildydqspagcrdallqlt
sgmvqthvttpgsipticdlartfaremgean

    Sequence, based on observed residues (ATOM records): (download) 
    >4oqxA (A:)
kmptllrvyidgphgmgkttttqllvasrddivyvpepmtywrvlgasetianiyttqhr
ldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeapppaltlifdrhpiaallc
ypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpgerldlam
laairrvygllantvrylqcggswredwgqlsgprphigdtlftlfrapellapngdlyn
vfawaldvlakrlrsmhvfildydqspagcrdallqltsgmvqthvttpgsipticdlar
tfaremge

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4oqxB (B:)
kmptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianiyttq
hrldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeagsshapppaltlifdrh
piaallcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpg
erldlamlaairrvygllantvrylqcggswredwgqlsgtavppqgaepqsnagprphi
gdtlftlfrapellapngdlynvfawaldvlakrlrsmhvfildydqspagcrdallqlt
sgmvqthvttpgsipticdlartfaremgean

    Sequence, based on observed residues (ATOM records): (download) 
    >4oqxB (B:)
mptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianiyttqh
rldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeapppaltlifdrhpiaall
cypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrgerldlamla
airrvygllantvrylqcggswredwgqlsgagprphigdtlftlfrapellapngdlyn
vfawaldvlakrlrsmhvfildydqspagcrdallqltsgmvqthvttpgsipticdlar
tfaremge