PDB entry 4oqv

View 4oqv on RCSB PDB site
Description: High resolution crystal structure of human dihydroorotate dehydrogenase bound with DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine)
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: Alpha/Beta Barrel, REDOX, DEHYDROGENASE, FMN, mitochondrial membrane, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2014-02-10, released 2014-06-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-07-09, with a file datestamp of 2014-07-03.
Experiment type: XRAY
Resolution: 1.23 Å
R-factor: 0.142
AEROSPACI score: 0.74 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH, Dihydroorotate Dehydrogenases
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4oqva_
  • Heterogens: FMN, ORO, 2V6, ACY, GOL, NA, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4oqvA (A:)
gderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnpv
giaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnsh
glsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvn
vsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvv
kelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiig
vggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaiga
dhrrdklaalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4oqvA (A:)
derfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnpvg
iaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshg
lsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnv
sspgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelgidgliv
tnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggvssgqda
lekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhr