PDB entry 4oq6

View 4oq6 on RCSB PDB site
Description: Crystal Structure of Human MCL-1 Bound to Inhibitor 4-hydroxy-4'-propylbiphenyl-3-carboxylic acid
Class: apoptosis/inhibitor
Keywords: APOPTOSIS-INHIBITOR complex
Deposited on 2014-02-07, released 2014-03-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-03-12, with a file datestamp of 2014-03-07.
Experiment type: XRAY
Resolution: 1.81 Å
R-factor: 0.203
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07820 (4-End)
      • expression tag (3)
    Domains in SCOPe 2.08: d4oq6a1, d4oq6a2
  • Chain 'B':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07820 (4-End)
      • expression tag (3)
    Domains in SCOPe 2.08: d4oq6b1, d4oq6b2
  • Heterogens: 2UV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4oq6A (A:)
gsmdlyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafq
gmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciep
laesitdvlvrtkrdwlvkqrgwdgfveffhvedleg

    Sequence, based on observed residues (ATOM records): (download) 
    >4oq6A (A:)
dlyrqsleiisrylreqatgaksgatsrkaletlrrvgdgvqrnhetafqgmlrkldikn
eddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaesitdvlv
rtkrdwlvkqrgwdgfveffh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4oq6B (B:)
gsmdlyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafq
gmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciep
laesitdvlvrtkrdwlvkqrgwdgfveffhvedleg

    Sequence, based on observed residues (ATOM records): (download) 
    >4oq6B (B:)
dlyrqsleiisrylreqatgakgatsrkaletlrrvgdgvqrnhetafqgmlrkldikne
ddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaesitdvlvr
tkrdwlvkqrgwdgfveffhv