PDB entry 4oq3

View 4oq3 on RCSB PDB site
Description: Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction
Class: ligase/ligase inhibitor
Keywords: PPI WITH P53, INHIBITOR COMPLEX, LIGASE-LIGASE INHIBITOR complex
Deposited on 2014-02-07, released 2014-04-23
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-05-21, with a file datestamp of 2014-05-16.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.196
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00987
      • engineered mutation (17)
    Domains in SCOPe 2.05: d4oq3a_
  • Chain 'B':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00987
      • engineered mutation (17)
    Domains in SCOPe 2.05: d4oq3b_
  • Chain 'C':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00987
      • engineered mutation (17)
    Domains in SCOPe 2.05: d4oq3c_
  • Chain 'D':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00987
      • engineered mutation (17)
    Domains in SCOPe 2.05: d4oq3d_
  • Heterogens: 2V8, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4oq3A (A:)
gsqipaseqetlvrpkpellkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhiv
ycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvn

    Sequence, based on observed residues (ATOM records): (download) 
    >4oq3A (A:)
qipaseqetlvrpkpellkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivyc
sndllgdlfgvpsfsvkehrkiytmiyrnlvvv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4oq3B (B:)
gsqipaseqetlvrpkpellkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhiv
ycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvn

    Sequence, based on observed residues (ATOM records): (download) 
    >4oq3B (B:)
qipaseqetlvrpkpellkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivyc
sndllgdlfgvpsfsvkehrkiytmiyrnlv

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4oq3C (C:)
gsqipaseqetlvrpkpellkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhiv
ycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvn

    Sequence, based on observed residues (ATOM records): (download) 
    >4oq3C (C:)
qipaseqetlvrpkpellkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivyc
sndllgdlfgvpsfsvkehrkiytmiyrnlvvv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4oq3D (D:)
gsqipaseqetlvrpkpellkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhiv
ycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvn

    Sequence, based on observed residues (ATOM records): (download) 
    >4oq3D (D:)
qipaseqetlvrpkpellkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivyc
sndllgdlfgvpsfsvkehrkiytmiyrnl