PDB entry 4opx

View 4opx on RCSB PDB site
Description: structure of human parp-1 bound to a dna double strand break in complex with (2r)-5-fluoro-2-methyl-2,3-dihydro-1-benzofuran-7- carboxamide
Deposited on 2014-02-06, released 2014-07-02
The last revision was dated 2017-07-26, with a file datestamp of 2017-07-21.
Experiment type: XRAY
Resolution: 3.31 Å
R-factor: N/A
AEROSPACI score: 0.1 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Poly [ADP-ribose] polymerase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PARP1, ADPRT, PPOL
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Poly [ADP-ribose] polymerase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PARP1, ADPRT, PPOL
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Poly [ADP-ribose] polymerase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PARP1, ADPRT, PPOL
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Poly [ADP-ribose] polymerase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PARP1, ADPRT, PPOL
    Database cross-references and differences (RAF-indexed):
  • Chain 'M':
    Compound: DNA (26-mer)
  • Chain 'N':
    Compound: DNA (26-mer)
  • Heterogens: ZN, 2UR

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4opxA (A:)
maessdklyrveyaksgrasckkcsesipkdslrmaimvqspmfdgkvphwyhfscfwkv
ghsirhpdvevdgfselrwddqqkvkktaeaggvtgkdikrkgdevdgvdevakkkskke
kdkdsklekalkaqndliwnikdelkkvcstndlkellifnkqqvpsgesaildrvadgm
vfgallpceecsgqlvfksdayyctgdvtawtkcmvktqtpnrkewvtpkefreisylkk
lkvkkqdrifppetsasvalehhhhhh

    Sequence, based on observed residues (ATOM records):
    >4opxA (A:)
dklyrveyaksgrasckkcsesipkdslrmaimvqspmfdgkvphwyhfscfwkvghsir
hpdvevdgfselrwddqqkvkktaeaskkekdkdsklekalkaqndliwnikdelkkvcs
tndlkellifnkqqvpsgesaildrvadgmvfgallpceecsgqlvfksdayyctgdvta
wtkcmvktqtpnrkewvtpkefreisylkklkvkkqdrifpp

  • Chain 'C':
    Sequence, based on SEQRES records:
    >4opxC (C:)
ksekrmkltlkggaavdpdsglehsahvlekggkvfsatlglvdivkgtnsyyklqlled
dkenrywifrswgrvgtvigsnkleqmpskedaiehfmklyeektgnawhsknftkypkk
fypleidygqdeeavkkltvnpgtksklpkpvqdlikmifdvesmkkamveyeidlqkmp
lgklskrqiqaaysilsevqqavsqgssdsqildlsnrfytliphdfgmkkppllnnads
vqakvemldnlldievaysllrggsddsskdpidvnyeklktdikvvdrdseeaeiirky
vknthatthnaydlevidifkieregecqrykpfkqlhnrrllwhgsrttnfagilsqgl
riappeapvtgymfgkgiyfadmvsksanychtsqgdpiglillgevalgnmyelkhash
isklpkgkhsvkglgkttpdpsanisldgvdvplgtgissgvndtsllyneyivydiaqv
nlkyllklkfnfktslwlehhhhhh

    Sequence, based on observed residues (ATOM records):
    >4opxC (C:)
aavdpdsglehsahvlekggkvfsatlglvdivkgtnsyyklqllwifrswgrvgtvigs
nkleqmpskedaiehfmklyeektgnawhsknftkypkkfypleidksklpkpvqdlikm
ifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqavsqgssdsqildlsnr
fytliphdfgmkkppllnnadsvqakvemldnlldievaysllrggsddsskdpidvnye
klktdikvvdrdseeaeiirkyvknthatthnaydlevidifkieregecqrykpfkqlh
nrrllwhgsrttnfagilsqglriappeapvtgymfgkgiyfadmvsksanychtsqgdp
iglillgevalgnmyelkhashisklpkgkhsvkglgkttpdpsanisldgvdvplgtgi
ssgvndtsllyneyivydiaqvnlkyllklkfnfkt

  • Chain 'D':
    Sequence, based on SEQRES records:
    >4opxD (D:)
maessdklyrveyaksgrasckkcsesipkdslrmaimvqspmfdgkvphwyhfscfwkv
ghsirhpdvevdgfselrwddqqkvkktaeaggvtgkdikrkgdevdgvdevakkkskke
kdkdsklekalkaqndliwnikdelkkvcstndlkellifnkqqvpsgesaildrvadgm
vfgallpceecsgqlvfksdayyctgdvtawtkcmvktqtpnrkewvtpkefreisylkk
lkvkkqdrifppetsasvalehhhhhh

    Sequence, based on observed residues (ATOM records):
    >4opxD (D:)
dklyrveyaksgrasckkcsesipkdslrmaimvqspmfdgkvphwyhfscfwkvghsir
hpdvevdgfselrwddqqkvkktaeaskkekdkdsklekalkaqndliwnikdelkkvcs
tndlkellifnkqqvpsgesaildrvadgmvfgallpceecsgqlvfksdayyctgdvta
wtkcmvktqtpnrkewvtpkefreisylkklkvkkqdrifpp

  • Chain 'F':
    Sequence, based on SEQRES records:
    >4opxF (F:)
ksekrmkltlkggaavdpdsglehsahvlekggkvfsatlglvdivkgtnsyyklqlled
dkenrywifrswgrvgtvigsnkleqmpskedaiehfmklyeektgnawhsknftkypkk
fypleidygqdeeavkkltvnpgtksklpkpvqdlikmifdvesmkkamveyeidlqkmp
lgklskrqiqaaysilsevqqavsqgssdsqildlsnrfytliphdfgmkkppllnnads
vqakvemldnlldievaysllrggsddsskdpidvnyeklktdikvvdrdseeaeiirky
vknthatthnaydlevidifkieregecqrykpfkqlhnrrllwhgsrttnfagilsqgl
riappeapvtgymfgkgiyfadmvsksanychtsqgdpiglillgevalgnmyelkhash
isklpkgkhsvkglgkttpdpsanisldgvdvplgtgissgvndtsllyneyivydiaqv
nlkyllklkfnfktslwlehhhhhh

    Sequence, based on observed residues (ATOM records):
    >4opxF (F:)
aavdpdsglehsahvlekggkvfsatlglvdivkgtnsyyklqllwifrswgrvgtvigs
nkleqmpskedaiehfmklyeektgnawhsknftkypkkfypleidksklpkpvqdlikm
ifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqavsqgssdsqildlsnr
fytliphdfgmkkppllnnadsvqakvemldnlldievaysllrggsddsskdpidvnye
klktdikvvdrdseeaeiirkyvknthatthnaydlevidifkieregecqrykpfkqlh
nrrllwhgsrttnfagilsqglriappeapvtgymfgkgiyfadmvsksanychtsqgdp
iglillgevalgnmyelkhashisklpkgkhsvkglgkttpdpsanisldgvdvplgtgi
ssgvndtsllyneyivydiaqvnlkyllklkfnfkt

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    No sequence available.