PDB entry 4ooe

View 4ooe on RCSB PDB site
Description: M. tuberculosis 1-deoxy-d-xylulose-5-phosphate reductoisomerase W203Y mutant bound to fosmidomycin and NADPH
Deposited on 2014-01-31, released 2014-06-18
The last revision was dated 2014-06-18, with a file datestamp of 2014-06-13.
Experiment type: XRAY
Resolution: 1.83 Å
R-factor: 0.17
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Gene: dxr, RVBD_2870c
    Database cross-references and differences (RAF-indexed):
    • Uniprot I6YAH0
      • engineered mutation (217)
  • Chain 'B':
    Compound: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Gene: dxr, RVBD_2870c
    Database cross-references and differences (RAF-indexed):
    • Uniprot I6YAH0 (Start-403)
      • engineered mutation (217)
  • Chain 'C':
    Compound: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Gene: dxr, RVBD_2870c
    Database cross-references and differences (RAF-indexed):
    • Uniprot I6YAH0
      • engineered mutation (217)
  • Chain 'D':
    Compound: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Gene: dxr, RVBD_2870c
    Database cross-references and differences (RAF-indexed):
    • Uniprot I6YAH0 (Start-403)
      • engineered mutation (217)
  • Heterogens: FOM, MN, NDP, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4ooeA (A:)
mhhhhhhlvrprgshmtnstdgradgrlrvvvlgstgsigtqalqviadnpdrfevvgla
aggahldtllrqraqtgvtniavadehaaqrvgdipyhgsdaatrlveqteadvvlnalv
galglrptlaalktgarlalankeslvaggslvlraarpgqivpvdsehsalaqclrggt
pdevaklvltasggpfrgwsaadlehvtpeqagahptysmgpmntlnsaslvnkglevie
thllfgipydridvvvhpqsiihsmvtfidgstiaqasppdmklpislalgwprrvsgaa
aacdfhtasswefepldtdvfpavelarqagvaggcmtavynaaneeaaaaflagrigfp
aivgiiadvlhaadqwavepatvddvldaqrwareraqravsgm

    Sequence, based on observed residues (ATOM records):
    >4ooeA (A:)
rlrvvvlgstgsigtqalqviadnpdrfevvglaaggahldtllrqraqtgvtniavade
haaqrvgdipyhgsdaatrlveqteadvvlnalvgalglrptlaalktgarlalankesl
vaggslvlraarpgqivpvdsehsalaqclrggtpdevaklvltasggpfrgwsaadleh
vtpeqagahptysmgpmntlnsaslvnkgleviethllfgipydridvvvhpqsiihsmv
tfidgstiaqasppdmklpislalgwprrvsgaaaacdfhtasswefepldtdvfpavel
arqagvaggcmtavynaaneeaaaaflagrigfpaivgiiadvlhaadqwavepatvddv
ldaqrwareraqravs

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4ooeB (B:)
mhhhhhhlvrprgshmtnstdgradgrlrvvvlgstgsigtqalqviadnpdrfevvgla
aggahldtllrqraqtgvtniavadehaaqrvgdipyhgsdaatrlveqteadvvlnalv
galglrptlaalktgarlalankeslvaggslvlraarpgqivpvdsehsalaqclrggt
pdevaklvltasggpfrgwsaadlehvtpeqagahptysmgpmntlnsaslvnkglevie
thllfgipydridvvvhpqsiihsmvtfidgstiaqasppdmklpislalgwprrvsgaa
aacdfhtasswefepldtdvfpavelarqagvaggcmtavynaaneeaaaaflagrigfp
aivgiiadvlhaadqwavepatvddvldaqrwareraqravsgm

    Sequence, based on observed residues (ATOM records):
    >4ooeB (B:)
rlrvvvlgstgsigtqalqviadnpdrfevvglaaggahldtllrqraqtgvtniavade
haaqrvgdipyhgsdaatrlveqteadvvlnalvgalglrptlaalktgarlalankesl
vaggslvlraarpgqivpvdsehsalaqclrggtpdevaklvltasggpfrgwsaadleh
vtpeqagahptysmgpmntlnsaslvnkgleviethllfgipydridvvvhpqsiihsmv
tfidgstiaqasppdmklpislalgwprrvsgaaaacdfhtasswefepldtdvfpavel
arqagvaggcmtavynaaneeaaaaflagrigfpaivgiiadvlhaadqwavepatvddv
ldaqrwareraqravsgm

  • Chain 'C':
    Sequence, based on SEQRES records:
    >4ooeC (C:)
mhhhhhhlvrprgshmtnstdgradgrlrvvvlgstgsigtqalqviadnpdrfevvgla
aggahldtllrqraqtgvtniavadehaaqrvgdipyhgsdaatrlveqteadvvlnalv
galglrptlaalktgarlalankeslvaggslvlraarpgqivpvdsehsalaqclrggt
pdevaklvltasggpfrgwsaadlehvtpeqagahptysmgpmntlnsaslvnkglevie
thllfgipydridvvvhpqsiihsmvtfidgstiaqasppdmklpislalgwprrvsgaa
aacdfhtasswefepldtdvfpavelarqagvaggcmtavynaaneeaaaaflagrigfp
aivgiiadvlhaadqwavepatvddvldaqrwareraqravsgm

    Sequence, based on observed residues (ATOM records):
    >4ooeC (C:)
rlrvvvlgstgsigtqalqviadnpdrfevvglaaggahldtllrqraqtgvtniavade
haaqrvgdipyhgsdaatrlveqteadvvlnalvgalglrptlaalktgarlalankesl
vaggslvlraarpgqivpvdsehsalaqclrggtpdevaklvltasggpfrgwsaadleh
vtpeqagahptysmgpmntlnsaslvnkgleviethllfgipydridvvvhpqsiihsmv
tfidgstiaqasppdmklpislalgwprrvsgaaaacdfhtasswefepldtdvfpavel
arqagvaggcmtavynaaneeaaaaflagrigfpaivgiiadvlhaadqwavepatvddv
ldaqrwareraqravsg

  • Chain 'D':
    Sequence, based on SEQRES records:
    >4ooeD (D:)
mhhhhhhlvrprgshmtnstdgradgrlrvvvlgstgsigtqalqviadnpdrfevvgla
aggahldtllrqraqtgvtniavadehaaqrvgdipyhgsdaatrlveqteadvvlnalv
galglrptlaalktgarlalankeslvaggslvlraarpgqivpvdsehsalaqclrggt
pdevaklvltasggpfrgwsaadlehvtpeqagahptysmgpmntlnsaslvnkglevie
thllfgipydridvvvhpqsiihsmvtfidgstiaqasppdmklpislalgwprrvsgaa
aacdfhtasswefepldtdvfpavelarqagvaggcmtavynaaneeaaaaflagrigfp
aivgiiadvlhaadqwavepatvddvldaqrwareraqravsgm

    Sequence, based on observed residues (ATOM records):
    >4ooeD (D:)
rlrvvvlgstgsigtqalqviadnpdrfevvglaaggahldtllrqraqtgvtniavade
haaqrvgdipyhgsdaatrlveqteadvvlnalvgalglrptlaalktgarlalankesl
vaggslvlraarpgqivpvdsehsalaqclrggtpdevaklvltasggpfrgwsaadleh
vtpeqagahptysmgpmntlnsaslvnkgleviethllfgipydridvvvhpqsiihsmv
tfidgstiaqasppdmklpislalgwprrvsgaaaacdfhtasswefepldtdvfpavel
arqagvaggcmtavynaaneeaaaaflagrigfpaivgiiadvlhaadqwavepatvddv
ldaqrwareraqravsgm