PDB entry 4ont

View 4ont on RCSB PDB site
Description: Ternary host recognition complex of complement factor H, C3d, and sialic acid
Class: immune system
Keywords: complement control protein, CCP, short consensus repeat, SCR, sushi domain, complement regulation, sialic acid, host glycan, host cell surface, IMMUNE SYSTEM
Deposited on 2014-01-29, released 2014-11-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: complement c3d fragment
    Species: Homo sapiens [TaxId:9606]
    Gene: C3, CPAMD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01024 (9-End)
      • expression tag (6-8)
      • engineered mutation (23)
    Domains in SCOPe 2.08: d4onta1, d4onta2
  • Chain 'B':
    Compound: complement c3d fragment
    Species: Homo sapiens [TaxId:9606]
    Gene: C3, CPAMD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01024
      • engineered mutation (23)
    Domains in SCOPe 2.08: d4ontb_
  • Chain 'C':
    Compound: complement c3d fragment
    Species: Homo sapiens [TaxId:9606]
    Gene: C3, CPAMD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01024 (9-End)
      • engineered mutation (23)
    Domains in SCOPe 2.08: d4ontc_
  • Chain 'D':
    Compound: complement factor h
    Species: Homo sapiens [TaxId:9606]
    Gene: CFH, HF, HF1, HF2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08603 (4-128)
      • expression tag (3)
  • Chain 'E':
    Compound: complement factor h
    Species: Homo sapiens [TaxId:9606]
    Gene: CFH, HF, HF1, HF2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08603 (4-128)
      • expression tag (3)
  • Chain 'F':
    Compound: complement factor h
    Species: Homo sapiens [TaxId:9606]
    Gene: CFH, HF, HF1, HF2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ontA (A:)
gplgspefrdaerlkhlivtpsgageqnmigmtptviavhyldeteqwekfglekrqgal
elikkgytqqlafrqpssafaafvkrapstwltayvvkvfslavnliaidsqvlcgavkw
lilekqkpdgvfqedapvihqemigglrnnnekdmaltafvlislqeakdiceeqvnslp
gsitkagdfleanymnlqrsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkq
lynveatsyallallqlkdfdfvppvvrwlneqryygggygstqatfmvfqalaqyqkda
pdhqelnldvslqlpsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4ontA (A:)
efrdaerlkhlivtpsgageqnmigmtptviavhyldeteqwekfglekrqgalelikkg
ytqqlafrqpssafaafvkrapstwltayvvkvfslavnliaidsqvlcgavkwlilekq
kpdgvfqedapvihqemigglrnnnekdmaltafvlislqeakdiceeqvnslpgsitka
gdfleanymnlqrsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkqlynvea
tsyallallqlkdfdfvppvvrwlneqryygggygstqatfmvfqalaqyqkdap

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ontB (B:)
gplgspefrdaerlkhlivtpsgageqnmigmtptviavhyldeteqwekfglekrqgal
elikkgytqqlafrqpssafaafvkrapstwltayvvkvfslavnliaidsqvlcgavkw
lilekqkpdgvfqedapvihqemigglrnnnekdmaltafvlislqeakdiceeqvnslp
gsitkagdfleanymnlqrsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkq
lynveatsyallallqlkdfdfvppvvrwlneqryygggygstqatfmvfqalaqyqkda
pdhqelnldvslqlpsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4ontB (B:)
tpsgageqnmigmtptviavhyldeteqwekfglekrqgalelikkgytqqlafrqpssa
faafvkrapstwltayvvkvfslavnliaidsqvlcgavkwlilekqkpdgvfqedapvi
hqemigglrnnnekdmaltafvlislqeakdiceeqvnslpgsitkagdfleanymnlqr
sytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkqlynveatsyallallqlkd
fdfvppvvrwlneqrgygstqatfmvfqalaqyqkdapdhqelldvslqlps

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4ontC (C:)
gplgspefrdaerlkhlivtpsgageqnmigmtptviavhyldeteqwekfglekrqgal
elikkgytqqlafrqpssafaafvkrapstwltayvvkvfslavnliaidsqvlcgavkw
lilekqkpdgvfqedapvihqemigglrnnnekdmaltafvlislqeakdiceeqvnslp
gsitkagdfleanymnlqrsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkq
lynveatsyallallqlkdfdfvppvvrwlneqryygggygstqatfmvfqalaqyqkda
pdhqelnldvslqlpsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4ontC (C:)
daerlkhlivtpsgageqnmigmtptviavhyldeteqwekfglekrqgalelikkgytq
qlafrqpssafaafvkrapstwltayvvkvfslavnliaidsqvlcgavkwlilekqkpd
gvfqedapvihqemigglrnnnekdmaltafvlislqeakdiceeqvnslpgsitkagdf
leanymnlqrsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkqlynveatsy
allallqlkdfdfvppvvrwlneqryygggygstqatfmvfqalaqyqkdap

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.