PDB entry 4obz

View 4obz on RCSB PDB site
Description: structure of cathepsin d with inhibitor 2-(3,4-dimethoxyphenyl)-n-[n- (4-methylbenzyl)carbamimidoyl]acetamide
Deposited on 2014-01-08, released 2014-08-13
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cathepsin D light chain
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSD, CTSD
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Cathepsin D heavy chain
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSD, CTSD
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Cathepsin D light chain
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSD, CTSD
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Cathepsin D heavy chain
    Species: Homo sapiens [TaxId:9606]
    Gene: CPSD, CTSD
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NAG, 2S4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4obzA (A:)
pavtegpipevlknymdaqyygeigigtppqcftvvfdtgssnlwvpsihcklldiacwi
hhkynsdksstyvkngtsfdihygsgslsgylsqdtvsvpcqs

    Sequence, based on observed residues (ATOM records):
    >4obzA (A:)
pipevlknymdaqyygeigigtppqcftvvfdtgssnlwvpsihcklldiacwihhkyns
dksstyvkngtsfdihygsgslsgylsqdtvsvpcqs

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4obzB (B:)
ggvkverqvfgeatkqpgitfiaakfdgilgmayprisvnnvlpvfdnlmqqklvdqnif
sfylsrdpdaqpggelmlggtdskyykgslsylnvtrkaywqvhldqvevasgltlckeg
ceaivdtgtslmvgpvdevrelqkaigavpliqgeymipcekvstlpaitlklggkgykl
spedytlkvsqagktlclsgfmgmdipppsgplwilgdvfigryytvfdrdnnrvgfaea
arl

    Sequence, based on observed residues (ATOM records):
    >4obzB (B:)
gvkverqvfgeatkqpgitfiaakfdgilgmayprisvnnvlpvfdnlmqqklvdqnifs
fylsrdpdaqpggelmlggtdskyykgslsylnvtrkaywqvhldqvevasgltlckegc
eaivdtgtslmvgpvdevrelqkaigavpliqgeymipcekvstlpaitlklggkgykls
pedytlkvsqagktlclsgfmgmdipppsgplwilgdvfigryytvfdrdnnrvgfaeaa

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >4obzC (C:)
pavtegpipevlknymdaqyygeigigtppqcftvvfdtgssnlwvpsihcklldiacwi
hhkynsdksstyvkngtsfdihygsgslsgylsqdtvsvpcqs

  • Chain 'D':
    Sequence, based on SEQRES records:
    >4obzD (D:)
ggvkverqvfgeatkqpgitfiaakfdgilgmayprisvnnvlpvfdnlmqqklvdqnif
sfylsrdpdaqpggelmlggtdskyykgslsylnvtrkaywqvhldqvevasgltlckeg
ceaivdtgtslmvgpvdevrelqkaigavpliqgeymipcekvstlpaitlklggkgykl
spedytlkvsqagktlclsgfmgmdipppsgplwilgdvfigryytvfdrdnnrvgfaea
arl

    Sequence, based on observed residues (ATOM records):
    >4obzD (D:)
ggvkverqvfgeatkqpgitfiaakfdgilgmayprisvnnvlpvfdnlmqqklvdqnif
sfylsrdpdaqpggelmlggtdskyykgslsylnvtrkaywqvhldqvevasgltlckeg
ceaivdtgtslmvgpvdevrelqkaigavpliqgeymipcekvstlpaitlklggkgykl
spedytlkvstlclsgfmgmdipppsgplwilgdvfigryytvfdrdnnrvgfaeaa