PDB entry 4obq

View 4obq on RCSB PDB site
Description: MAP4K4 in complex with inhibitor (compound 31), N-[3-(4-AMINOQUINAZOLIN-6-YL)-5-FLUOROPHENYL]-2-(PYRROLIDIN-1-YL)ACETAMIDE
Class: transferase/transferase inhibitor
Keywords: kinase, transferase-transferase inhibitor complex
Deposited on 2014-01-07, released 2014-04-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-05-07, with a file datestamp of 2014-05-02.
Experiment type: XRAY
Resolution: 2.19 Å
R-factor: 0.207
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase kinase kinase kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: HGK, KIAA0687, MAP4K4, NIK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4obqa_
  • Chain 'B':
    Compound: Mitogen-activated protein kinase kinase kinase kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: HGK, KIAA0687, MAP4K4, NIK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4obqb_
  • Heterogens: MES, MG, 2QT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4obqA (A:)
gsandspakslvdidlsslrdpagifelvevvgngtygqvykgrhvktgqlaaikvmdvt
edeeeeikleinmlkkyshhrniatyygafikksppghddqlwlvmefcgagsitdlvkn
tkgntlkedwiayisreilrglahlhihhvihrdikgqnvlltenaevklvdfgvsaqld
rtvgrrntfigtpywmapeviacdenpdatydyrsdlwscgitaiemaegapplcdmhpm
ralfliprnppprlkskkwskkffsfiegclvknymqrpsteqllkhpfirdqpnerqvr
iqlkdhidrtrkkrgekdeteyeysgseegns

    Sequence, based on observed residues (ATOM records): (download) 
    >4obqA (A:)
sslrdpagifelvevvgngtygqvykgrhvktgqlaaikvmdveinmlkkyshhrniaty
ygafikksppghddqlwlvmefcgagsitdlvkntkgntlkedwiayisreilrglahlh
ihhvihrdikgqnvlltenaevklvdfgvntfigtpywmapeviacdenpdatydyrsdl
wscgitaiemaegapplcdmhpmralfliprnppprlkskkwskkffsfiegclvknymq
rpsteqllkhpfirdqpnerqvriqlkdhidrtrk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4obqB (B:)
gsandspakslvdidlsslrdpagifelvevvgngtygqvykgrhvktgqlaaikvmdvt
edeeeeikleinmlkkyshhrniatyygafikksppghddqlwlvmefcgagsitdlvkn
tkgntlkedwiayisreilrglahlhihhvihrdikgqnvlltenaevklvdfgvsaqld
rtvgrrntfigtpywmapeviacdenpdatydyrsdlwscgitaiemaegapplcdmhpm
ralfliprnppprlkskkwskkffsfiegclvknymqrpsteqllkhpfirdqpnerqvr
iqlkdhidrtrkkrgekdeteyeysgseegns

    Sequence, based on observed residues (ATOM records): (download) 
    >4obqB (B:)
idlsslrdpagifelvevgqvykgrhvktgqlaaikvmdvtedeeeeikleinmlkkysh
hrniatyygafikksppghddqlwlvmefcgagsitdlvkntkgntlkedwiayisreil
rglahlhihhvihrdikgqnvlltenaevklvdfgvsaqldrtvgrrntfigtpywmape
viacdenpdatydyrsdlwscgitaiemaegapplcdmhpmralfliprnppprlkskkw
skkffsfiegclvknymqrpsteqllkhpfirdqpnerqvriqlkdhidrtrk