PDB entry 4o9h

View 4o9h on RCSB PDB site
Description: Structure of Interleukin-6 in complex with a Camelid Fab fragment
Class: immune system
Keywords: IL6: all alpha protein, Fab: all beta protein, IMMUNE SYSTEM
Deposited on 2014-01-02, released 2015-04-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-04-29, with a file datestamp of 2015-04-24.
Experiment type: XRAY
Resolution: 2.42 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: interleukin-6
    Species: Homo sapiens [TaxId:9606]
    Gene: IL6, IFNB2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4o9ha_
  • Chain 'H':
    Compound: Heavy Chain of the Camelid Fab fragment 61H7
    Species: Llama Glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 4O9H (0-End)
    Domains in SCOPe 2.08: d4o9hh_
  • Chain 'L':
    Compound: Light Chain of the Camelid Fab fragment 61H7
    Species: Llama Glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 4O9H (0-End)
    Domains in SCOPe 2.08: d4o9hl1, d4o9hl2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4o9hA (A:)
mapvppgedskdvaaphrqpltsseridkqiryildgisalrketcnksnmcesskeala
ennlnlpkmaekdgcfqsgfneetclvkiitgllefevyleylqnrfesseeqaravqms
tkvliqflqkkaknldaittpdpttnaslltklqaqnqwlqdmtthlilrsfkeflqssl
ralrqm

    Sequence, based on observed residues (ATOM records): (download) 
    >4o9hA (A:)
ltsseridkqiryildgisalrketcnksnnlnlpkmaekdgcfqsgfneetclvkiitg
llefevyleylqnrsseeqaravqmstkvliqflqkkaknldaittpdpttnaslltklq
aqnqwlqdmtthlilrsfkeflqsslralrqm

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4o9hH (H:)
evqlvesggglvqpggslrlscaasgftfssyrmywvrqppgkglewvsaisagggstyy
gdsvkgrftisrdnakntvylqmnslkpedtavyycanragwgmgdywgqgtqvtvssas
tkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdk

    Sequence, based on observed residues (ATOM records): (download) 
    >4o9hH (H:)
evqlvesggglvqpggslrlscaasgftfssyrmywvrqppgkglewvsaisagggstyy
gdsvkgrftisrdnakntvylqmnslkpedtavyycanragwgmgdywgqgtqvtvssas
tkgpsvfplapssktaalgclvkdyfpepvtvswngvhtfpavlqssglyslssvvttyi
cnvnhkpsntkvdkkvepks

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >4o9hL (L:)
qtvvtqepslsvspggtvtltcglssgsvtasnypgwfqqtpgqapraliystndrhsgv
psrfsgsisgnkaaltitgaqpedeadyycaldigditefgggthltvlgqpkaapsvtl
fppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassy
lsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >4o9hL (L:)
qtvvtqepslsvspggtvtltcglssgsvtasnypgwfqqtpgqapraliystndrhsgv
psrfsgsisgnkaaltitgaqpedeadyycaldigditefgggthltvlgqpkaapsvtl
fppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassy
lsltpeqwkshrsyscqvthegstvektvap