PDB entry 4o76

View 4o76 on RCSB PDB site
Description: Crystal structure of the first bromodomain of human BRD4 in complex with TG101209
Class: transcription/inhibitor
Keywords: BROMODOMAIN, CAP, HUNK1, MCAP, PROTEIN BINDING-INHIBITOR COMPLEX, MITOTIC CHROMOSOME ASSOCIATED PROTEIN, CELL CYCLE, INHIBITOR, TRANSCRIPTION-INHIBITOR complex
Deposited on 2013-12-24, released 2014-03-05
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-05-28, with a file datestamp of 2014-05-23.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.136
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (2-126)
      • expression tag (0-1)
    Domains in SCOPe 2.07: d4o76a1, d4o76a2
  • Chain 'B':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (2-126)
      • expression tag (0-1)
    Domains in SCOPe 2.07: d4o76b1, d4o76b2
  • Chain 'C':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (2-126)
      • expression tag (0-1)
    Domains in SCOPe 2.07: d4o76c1, d4o76c2
  • Chain 'D':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (2-126)
      • expression tag (0-1)
    Domains in SCOPe 2.07: d4o76d1, d4o76d2
  • Heterogens: 1M3, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4o76A (A:)
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelptee

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4o76B (B:)
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelptee

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4o76C (C:)
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelptee

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4o76D (D:)
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelptee