PDB entry 4o6z

View 4o6z on RCSB PDB site
Description: Crystal structure of serine hydroxymethyltransferase with covalently bound PLP Schiff-base from Plasmodium falciparum
Class: transferase
Keywords: alpha/beta protein, Transferase, methyltransferase activity, Cytosol
Deposited on 2013-12-24, released 2014-06-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-18, with a file datestamp of 2019-12-13.
Experiment type: XRAY
Resolution: 2.98 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine hydroxymethyltransferase
    Species: PLASMODIUM FALCIPARUM [TaxId:36329]
    Gene: PFL1720w, SHMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8I566 (38-479)
      • expression tag (32-37)
      • engineered mutation (329)
    Domains in SCOPe 2.08: d4o6za1, d4o6za2
  • Chain 'B':
    Compound: serine hydroxymethyltransferase
    Species: PLASMODIUM FALCIPARUM [TaxId:36329]
    Gene: PFL1720w, SHMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8I566 (38-479)
      • expression tag (35-37)
      • engineered mutation (329)
    Domains in SCOPe 2.08: d4o6zb1, d4o6zb2
  • Chain 'C':
    Compound: serine hydroxymethyltransferase
    Species: PLASMODIUM FALCIPARUM [TaxId:36329]
    Gene: PFL1720w, SHMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8I566 (Start-479)
      • engineered mutation (329)
    Domains in SCOPe 2.08: d4o6zc_
  • Chain 'D':
    Compound: serine hydroxymethyltransferase
    Species: PLASMODIUM FALCIPARUM [TaxId:36329]
    Gene: PFL1720w, SHMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8I566 (38-479)
      • expression tag (35-37)
      • engineered mutation (329)
    Domains in SCOPe 2.08: d4o6zd1, d4o6zd2
  • Heterogens: PLP, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4o6zA (A:)
    mrgshhhhhhgmasmtggqqmgrdlyddddkdhpftpgmfnndplqkydkelfdllekek
    nrqietinliasenltntavreclgdrisnkysegyphkryyggndyvdkieelcykral
    eafnvseeewgvnvqplsgsaanvqalyalvgvkgkimgmhlcsgghlthgffdekkkvs
    itsdlfesklykcnsegyvdmesvrnlalsfqpkviicgytsyprdidykgfreicdevn
    aylfadishissfvacnllnnpftyadvvtttthkilrgprsaliffnkkrnpgidqkin
    ssvfpsfqggphnnkiaavacqlkevntpefkeytkqvllnskalaecllkrnldlvtng
    tdnhlivvdlrkynitgsklqetcnainialnkntipsdvdcvspsgirigtpalttrgc
    kekdmefiadmllkailltdelqqkygkklvdfkkglvnnpkidelkkevvqwaknlpfa
    

    Sequence, based on observed residues (ATOM records): (download)
    >4o6zA (A:)
    hpftpgmfnndplqkydkelfdllekeknrqietinliasenltntavreclgdrisnky
    segyphkryyggndyvdkieelcykraleafnvseeewgvnvqplsgsaanvqalyalvg
    vkgkimgmhlcsgghlthgffdekkkvsitsdlfesklykcnsegyvdmesvrnlalsfq
    pkviicgytsyprdidykgfreicdevnaylfadishissfvacnllnnpftyadvvttt
    thkilrgprsaliffnkkrnpgidqkinssvfpsfqggphnnkiaavacqlkevntpefk
    eytkqvllnskalaecllkrnldlvtngtdnhlivvdlrkynitgsklqetcnainialn
    kntipsdvdcvspsgirigtpalttrgckekdmefiadmllkailltdelqqkygkklvd
    fkkglvnnpkidelkkevvqwaknlpfa
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4o6zB (B:)
    mrgshhhhhhgmasmtggqqmgrdlyddddkdhpftpgmfnndplqkydkelfdllekek
    nrqietinliasenltntavreclgdrisnkysegyphkryyggndyvdkieelcykral
    eafnvseeewgvnvqplsgsaanvqalyalvgvkgkimgmhlcsgghlthgffdekkkvs
    itsdlfesklykcnsegyvdmesvrnlalsfqpkviicgytsyprdidykgfreicdevn
    aylfadishissfvacnllnnpftyadvvtttthkilrgprsaliffnkkrnpgidqkin
    ssvfpsfqggphnnkiaavacqlkevntpefkeytkqvllnskalaecllkrnldlvtng
    tdnhlivvdlrkynitgsklqetcnainialnkntipsdvdcvspsgirigtpalttrgc
    kekdmefiadmllkailltdelqqkygkklvdfkkglvnnpkidelkkevvqwaknlpfa
    

    Sequence, based on observed residues (ATOM records): (download)
    >4o6zB (B:)
    tpgmfnndplqkydkelfdllekeknrqietinliasenltntavreclgdrisnkyseg
    yphkryyggndyvdkieelcykraleafnvseeewgvnvqplsgsaanvqalyalvgvkg
    kimgmhlcsgghlthgffdekkkvsitsdlfesklykcnsegyvdmesvrnlalsfqpkv
    iicgytsyprdidykgfreicdevnaylfadishissfvacnllnnpftyadvvtttthk
    ilrgprsaliffnkkrnpgidqkinssvfpsfqggphnnkiaavacqlkevntpefkeyt
    kqvllnskalaecllkrnldlvtngtdnhlivvdlrkynitgsklqetcnainialnknt
    ipsdvdcvspsgirigtpalttrgckekdmefiadmllkailltdelqqkygkklvdfkk
    glvnnpkidelkkevvqwaknlpfa
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4o6zC (C:)
    mrgshhhhhhgmasmtggqqmgrdlyddddkdhpftpgmfnndplqkydkelfdllekek
    nrqietinliasenltntavreclgdrisnkysegyphkryyggndyvdkieelcykral
    eafnvseeewgvnvqplsgsaanvqalyalvgvkgkimgmhlcsgghlthgffdekkkvs
    itsdlfesklykcnsegyvdmesvrnlalsfqpkviicgytsyprdidykgfreicdevn
    aylfadishissfvacnllnnpftyadvvtttthkilrgprsaliffnkkrnpgidqkin
    ssvfpsfqggphnnkiaavacqlkevntpefkeytkqvllnskalaecllkrnldlvtng
    tdnhlivvdlrkynitgsklqetcnainialnkntipsdvdcvspsgirigtpalttrgc
    kekdmefiadmllkailltdelqqkygkklvdfkkglvnnpkidelkkevvqwaknlpfa
    

    Sequence, based on observed residues (ATOM records): (download)
    >4o6zC (C:)
    fnndplqkydkelfdllekeknrqietinliasenltntavreclgdrisnkysegyphk
    ryyggndyvdkieelcykraleafnvseeewgvnvqplsgsaanvqalyalvgvkgkimg
    mhlcsgghlthgffdekkkvsitsdlfesklykcnsegyvdmesvrnlalsfqpkviicg
    ytsyprdidykgfreicdevnaylfadishissfvacnllnnpftyadvvtttthkilrg
    prsaliffnkkrnpgidqkinssvfpsfqggphnnkiaavacqlkevntpefkeytkqvl
    lnskalaecllkrnldlvtngtdnhlivvdlrkynitgsklqetcnainialnkntipsd
    vdcvspsgirigtpalttrgckekdmefiadmllkailltdelqqkygkklvdfkkglvn
    npkidelkkevvqwaknlpfa
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4o6zD (D:)
    mrgshhhhhhgmasmtggqqmgrdlyddddkdhpftpgmfnndplqkydkelfdllekek
    nrqietinliasenltntavreclgdrisnkysegyphkryyggndyvdkieelcykral
    eafnvseeewgvnvqplsgsaanvqalyalvgvkgkimgmhlcsgghlthgffdekkkvs
    itsdlfesklykcnsegyvdmesvrnlalsfqpkviicgytsyprdidykgfreicdevn
    aylfadishissfvacnllnnpftyadvvtttthkilrgprsaliffnkkrnpgidqkin
    ssvfpsfqggphnnkiaavacqlkevntpefkeytkqvllnskalaecllkrnldlvtng
    tdnhlivvdlrkynitgsklqetcnainialnkntipsdvdcvspsgirigtpalttrgc
    kekdmefiadmllkailltdelqqkygkklvdfkkglvnnpkidelkkevvqwaknlpfa
    

    Sequence, based on observed residues (ATOM records): (download)
    >4o6zD (D:)
    tpgmfnndplqkydkelfdllekeknrqietinliasenltntavreclgdrisnkyseg
    yphkryyggndyvdkieelcykraleafnvseeewgvnvqplsgsaanvqalyalvgvkg
    kimgmhlcsgghlthgffdekkkvsitsdlfesklykcnsegyvdmesvrnlalsfqpkv
    iicgytsyprdidykgfreicdevnaylfadishissfvacnllnnpftyadvvtttthk
    ilrgprsaliffnkkrnpgidqkinssvfpsfqggphnnkiaavacqlkevntpefkeyt
    kqvllnskalaecllkrnldlvtngtdnhlivvdlrkynitgsklqetcnainialnknt
    ipsdvdcvspsgirigtpalttrgckekdmefiadmllkailltdelqqkygkklvdfkk
    glvnnpkidelkkevvqwaknlpfa