PDB entry 4o6e
View 4o6e on RCSB PDB site
Description: Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine Inhibitors of Erk2
Class: transferase/transferase inhibitor
Keywords: protein Kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2013-12-20, released
2014-05-21
The last revision prior to the SCOPe 2.08 freeze date was dated
2014-06-25, with a file datestamp of
2014-06-20.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.183
AEROSPACI score: 0.39
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Mitogen-activated protein kinase 1
Species: Homo sapiens [TaxId:9606]
Gene: MAPK1, ERK2, PRKM1, PRKM2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4o6ea_ - Heterogens: 2SH, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4o6eA (A:)
mgsshhhhhhssglvprgshmvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrva
ikkispfehqtycqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetdl
ykllktqhlsndhicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglar
vadpdhdhtgflteyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkh
yldqlnhilgilgspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldk
mltfnphkrieveqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeeta
rfqpgyrs
Sequence, based on observed residues (ATOM records): (download)
>4o6eA (A:)
mvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlrei
killrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyq
ilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpvatrwyrapeimlnyt
ksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnciinlkarnylls
lphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyydpsdepiae
apfkelddlpkeklkelifeetarfqpg