PDB entry 4o49

View 4o49 on RCSB PDB site
Description: Crystal structure of the vaccine antigen Transferrin Binding Protein B (TbpB) mutant Tyr-174-Ala from Actinobacillus pleuropneumoniae H87
Class: metal transport
Keywords: Structure-based vaccine design, transferrin receptor, iron acquisition, host pathogen interaction, surface lipoprotein, METAL TRANSPORT
Deposited on 2013-12-18, released 2015-01-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-03-04, with a file datestamp of 2015-02-27.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Outer membrane protein; transferrin-binding protein
    Species: Actinobacillus pleuropneumoniae [TaxId:715]
    Gene: tfbA
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q44167 (Start-522)
      • conflict (113)
      • engineered mutation (168)
    Domains in SCOPe 2.08: d4o49a1, d4o49a2, d4o49a3, d4o49a4
  • Heterogens: GOL, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4o49A (A:)
gsfdlddvqpnkavepektkvnytdeetqkrkkeeldklmepalgyvtkipvnipsvrkt
eiseidtvtdeslslvpnedklrtianenygsvvtksgsntmnfvrsgytidvvhyglrd
kgyvyykgvhpskelpkgniivyqgewdftsnadldakrpnynpefngagagqrvgvtsa
dakertyiskfnidfsnkklngqlltktkenqeklrytveanisgnrfrgkatatdktdp
ilgkdsehlegglygpkseelagkfvahdkslfavfsgkrgndvletvkiidaskidltt
fesselnnfgnanvliidgqkidlagadfknrktvdingktmvaiaccsnleymkfgqlw
qkegeqtkdnslflqgertatdkipvggnykyvgtwdalvskgtnwvaeadnnresgyrs
efdvnfgdkkvsgklfdkggivpvfminadikgngftgtanttdtgfaldsgssqhgnav
fsdikvnggfygptagelggqfhhksdngsvgavfgakrqiek

    Sequence, based on observed residues (ATOM records): (download) 
    >4o49A (A:)
vnytdeetqkrkkeeldklmepalgyvtkipvnipsvrkteiseidtvtdeslslvpned
klrtianenygsvvtksgsntmnfvrsgytidvvhyglrdkgyvyykgvhpskelpkgni
ivyqgewdftsnadldakrpnynpefngagagqrvgvtsadakertyiskfnidfsnkkl
ngqlltktkenqeklrytveanisgnrfrgkatatdktdpilgkdsehlegglygpksee
lagkfvahdkslfavfsgkrgndvletvkiidaskidlttfesselnnfgnanvliidgq
kidlagadfknrktvdingktmvaiaccsnleymkfgqlwqkegeqtkdnslflqgerta
tdkipvggnykyvgtwdalvskgtnwvaeadnnresgyrsefdvnfgdkkvsgklfdkgg
ivpvfminadikgngftgtanttdtgfaldsqhgnavfsdikvnggfygptagelggqfh
hksdngsvgavfgakrqiek