PDB entry 4o2p

View 4o2p on RCSB PDB site
Description: Kinase domain of cSrc in complex with a substituted pyrazolopyrimidine
Class: transferase/transferase inhibitor
Keywords: pyrazolo-pyrimidine ligand, type I, dfg-in, tyrosine protein kinase, transferase-transferase inhibitor complex
Deposited on 2013-12-17, released 2015-03-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-03-04, with a file datestamp of 2015-02-27.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC, v-Src sarcoma viral oncogene
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4o2pa_
  • Chain 'B':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC, v-Src sarcoma viral oncogene
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4o2pb_
  • Heterogens: 11V, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4o2pA (A:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >4o2pA (A:)
kdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpmspeaflqeaqvmkklr
heklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdmaaqiasgmayve
rmnyvhrdlraanilvgenlvckvadfglarliedfpikwtapeaalygrftiksdvwsf
gilltelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerpt
feylqafledyftstepqyqpgenl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4o2pB (B:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >4o2pB (B:)
akdaweipreslrlevklgqgfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvmkk
lrheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdmaaqiasgmay
vermnyvhrdlraanilvgenlvckvadfglarlifpikwtapeaalygrftiksdvwsf
gilltelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerpt
feylqafledyftstepqyqpgenl