PDB entry 4o28

View 4o28 on RCSB PDB site
Description: Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors
Class: transferase/transferase inhibitor
Keywords: TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-12-17, released 2014-10-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-10-22, with a file datestamp of 2014-10-17.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.152
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nicotinamide phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: NAMPT, PBEF, PBEF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P43490
      • engineered mutation (164)
    Domains in SCOPe 2.08: d4o28a1, d4o28a2
  • Chain 'B':
    Compound: Nicotinamide phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: NAMPT, PBEF, PBEF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P43490
      • engineered mutation (164)
    Domains in SCOPe 2.08: d4o28b1, d4o28b2
  • Heterogens: 1QS, PO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4o28A (A:)
mnpaaeaefnillatdsykvthykqyppntskvysyfecrekktensklrkvkyeetvfy
glqyilnkylkgkvvtkekiqeakdvykehfqddvfnekgwnyilekydghlpieikavp
egfviprgnvlftventdpecywltnwietilvqswypitvatnfreqkkilakyllets
gnldgleyklhdfgyrgvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgy
svpaaehstitawgkdhekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhliv
srstqapliirpdsgnpldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdint
lqeivegmkqkmwsieniafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvad
pnkrskkgrlslhrtpagnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirkna
qlnieleaahhlehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4o28A (A:)
efnillatdsykvthykqyppntskvysyfecrekyeetvfyglqyilnkylkgkvvtke
kiqeakdvykehfqddvfnekgwnyilekydghlpieikavpegfviprgnvlftventd
pecywltnwietilvqswypitvatnfreqkkilakylletsgnldgleyklhdfgyrgv
ssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgysvpaaehstitawgkdhe
kdafehivtqfssvpvsvvsdsydiynacekiwgedlrhlivsrstqapliirpdsgnpl
dtvlkvleilgkkfpvtenskgykllppylrviqgdgvdintlqeivegmkqkmwsieni
afgsgqkltrdllncsfkcsyvvtnglginvfkdpvadpnkrskkgrlslhrtpagnfvt
leegkgdleeygqdllhtvfkngkvtksysfdeirknaqlniele

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4o28B (B:)
mnpaaeaefnillatdsykvthykqyppntskvysyfecrekktensklrkvkyeetvfy
glqyilnkylkgkvvtkekiqeakdvykehfqddvfnekgwnyilekydghlpieikavp
egfviprgnvlftventdpecywltnwietilvqswypitvatnfreqkkilakyllets
gnldgleyklhdfgyrgvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgy
svpaaehstitawgkdhekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhliv
srstqapliirpdsgnpldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdint
lqeivegmkqkmwsieniafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvad
pnkrskkgrlslhrtpagnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirkna
qlnieleaahhlehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4o28B (B:)
efnillatdsykvthykqyppntskvysyfecrekkyeetvfyglqyilnkylkgkvvtk
ekiqeakdvykehfqddvfnekgwnyilekydghlpieikavpegfviprgnvlftvent
dpecywltnwietilvqswypitvatnfreqkkilakylletsgnldgleyklhdfgyrg
vssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgysvpaaehstitawgkdh
ekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhlivsrstqapliirpdsgnp
ldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdintlqeivegmkqkmwsien
iafgskltrdllncsfkcsyvvtnglginvfkdpvadpnkrskkgrlslhrtpagnfvtl
eegkgdleeygqdllhtvfkngkvtksysfdeirknaqlniele