PDB entry 4o22

View 4o22 on RCSB PDB site
Description: Binary complex of metal-free PKAc with SP20.
Class: hydrolase/hydrolase inhibitor
Keywords: Ser/Thr kinase, phosphoryl transfer, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2013-12-16, released 2014-05-28
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-05-28, with a file datestamp of 2014-05-23.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.187
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-dependent protein kinase catalytic subunit alpha.
    Species: Mus musculus [TaxId:10090]
    Gene: Pkaca, Prkaca, Prkaca Pkaca
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05132 (6-341)
      • expression tag (3-5)
    Domains in SCOPe 2.05: d4o22a_
  • Chain 'S':
    Compound: Phosphorylated peptide pSP20.
    Species: Homo sapiens [TaxId:9606]
    Gene: PKIA, PKIA PRKACN1, PRKACN1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61925 (0-19)
      • engineered mutation (15-16)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4o22A (A:)
hhhhhhvkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlvkhkesgnh
yamkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvaggem
fshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfa
krvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiye
kivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqr
kveapfipkfkgpgdtsnfddyeeeeirvsinekcgkeftef

    Sequence, based on observed residues (ATOM records): (download) 
    >4o22A (A:)
hhhvkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlvkhkesgnhyam
kildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvaggemfsh
lrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrv
kgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekiv
sgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkve
apfipkfkgpgdtsnfddyeeeeirvsinekcgkeftef

  • Chain 'S':
    No sequence available.