PDB entry 4o21

View 4o21 on RCSB PDB site
Description: Product complex of metal-free PKAc, ATP-gamma-S and SP20.
Class: hydrolase/hydrolase inhibitor
Keywords: Ser/Thr kinase, phosphoryl transfer, nucleotide, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2013-12-16, released 2014-05-28
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-05-28, with a file datestamp of 2014-05-23.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.17
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-dependent protein kinase catalytic subunit alpha
    Species: Mus musculus [TaxId:10090]
    Gene: Pkaca, Prkaca, Prkaca Pkaca
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4o21a_
  • Chain 'S':
    Compound: Thio-phosphorylated peptide pSP20
    Species: Homo sapiens [TaxId:9606]
    Gene: PKIA, PKIA PRKACN1, PRKACN1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61925 (0-19)
      • engineered mutation (15-16)
  • Heterogens: ADP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4o21A (A:)
    hhhhhhvkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlvkhkesgnh
    yamkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvaggem
    fshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfa
    krvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiye
    kivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqr
    kveapfipkfkgpgdtsnfddyeeeeirvsinekcgkeftef
    

    Sequence, based on observed residues (ATOM records): (download)
    >4o21A (A:)
    vkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlvkhkesgnhyamkil
    dkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvaggemfshlrr
    igrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrvkgr
    twtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekivsgk
    vrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkveapf
    ipkfkgpgdtsnfddyeeeeirvsinekcgkeftef
    

  • Chain 'S':
    No sequence available.