PDB entry 4o19

View 4o19 on RCSB PDB site
Description: The crystal structure of a mutant NAMPT (G217V)
Class: transferase
Keywords: transferase
Deposited on 2013-12-15, released 2014-10-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-10-22, with a file datestamp of 2014-10-17.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.155
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nicotinamide phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: NAMPT, PBEF, PBEF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P43490
      • engineered mutation (216)
    Domains in SCOPe 2.08: d4o19a1, d4o19a2
  • Chain 'B':
    Compound: Nicotinamide phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: NAMPT, PBEF, PBEF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P43490
      • engineered mutation (216)
    Domains in SCOPe 2.08: d4o19b1, d4o19b2
  • Heterogens: PO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4o19A (A:)
mnpaaeaefnillatdsykvthykqyppntskvysyfecrekktensklrkvkyeetvfy
glqyilnkylkgkvvtkekiqeakdvykehfqddvfnekgwnyilekydghlpieikavp
egfviprgnvlftventdpecywltnwietilvqswypitvatnsreqkkilakyllets
gnldgleyklhdfgyrgvssqetagigasahlvnfkvtdtvaglalikkyygtkdpvpgy
svpaaehstitawgkdhekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhliv
srstqapliirpdsgnpldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdint
lqeivegmkqkmwsieniafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvad
pnkrskkgrlslhrtpagnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirkna
qlnieleaahhlehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4o19A (A:)
efnillatdsykvthykqyppntskvysyfecrekkkyeetvfyglqyilnkylkgkvvt
kekiqeakdvykehfqddvfnekgwnyilekydghlpieikavpegfviprgnvlftven
tdpecywltnwietilvqswypitvatnsreqkkilakylletsgnldgleyklhdfgyr
gvssqetagigasahlvnfkvtdtvaglalikkyygtkdpvpgysvpaaehstitawgkd
hekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhlivsrstqapliirpdsgn
pldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdintlqeivegmkqkmwsie
niafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvadpnkrskkgrlslhrtp
agnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirknaqlniele

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4o19B (B:)
mnpaaeaefnillatdsykvthykqyppntskvysyfecrekktensklrkvkyeetvfy
glqyilnkylkgkvvtkekiqeakdvykehfqddvfnekgwnyilekydghlpieikavp
egfviprgnvlftventdpecywltnwietilvqswypitvatnsreqkkilakyllets
gnldgleyklhdfgyrgvssqetagigasahlvnfkvtdtvaglalikkyygtkdpvpgy
svpaaehstitawgkdhekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhliv
srstqapliirpdsgnpldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdint
lqeivegmkqkmwsieniafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvad
pnkrskkgrlslhrtpagnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirkna
qlnieleaahhlehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4o19B (B:)
efnillatdsykvthykqyppntskvysyfecrekkyeetvfyglqyilnkylkgkvvtk
ekiqeakdvykehfqddvfnekgwnyilekydghlpieikavpegfviprgnvlftvent
dpecywltnwietilvqswypitvatnsreqkkilakylletsgnldgleyklhdfgyrg
vssqetagigasahlvnfkvtdtvaglalikkyygtkdpvpgysvpaaehstitawgkdh
ekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhlivsrstqapliirpdsgnp
ldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdintlqeivegmkqkmwsien
iafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvadpnkrskkgrlslhrtpa
gnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirknaqlniel