PDB entry 4o0r

View 4o0r on RCSB PDB site
Description: Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors
Class: transferase/transferase inhibitor
Keywords: PAK1, transferase-transferase inhibitor complex
Deposited on 2013-12-14, released 2014-02-12
The last revision prior to the SCOPe 2.03 freeze date was dated 2014-02-12, with a file datestamp of 2014-02-07.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.208
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase PAK 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PAK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13153 (0-End)
      • conflict (140)
      • conflict (174)
    Domains in SCOPe 2.03: d4o0ra_
  • Chain 'B':
    Compound: Serine/threonine-protein kinase PAK 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PAK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13153 (0-End)
      • conflict (140)
      • conflict (174)
    Domains in SCOPe 2.03: d4o0rb_
  • Heterogens: X4Z, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4o0rA (A:)
sdeeileklrsivsvgdpkkkytrfekigqgasgtvytamdvatgqevaikqmnlqqqpk
keliineilvmrenknpnivnyldsylvgdelwvvmeylaggsltdvvtetcmdegqiaa
vcreclqaleflhsnqvihrniksdnillgmdgsvkltdfgfcaqitpeqskrsemvgtp
ywmapevvtrkaygpkvdiwslgimaiemiegeppylnenplralyliatngtpelqnpe
klsaifrdflnrclemdvekrgsakellqhqflkiakplssltpliaaakeatknnhgns

    Sequence, based on observed residues (ATOM records): (download) 
    >4o0rA (A:)
sdeeileklrsivsvgdpkkkytrfekigqgasgtvytamdvatgqevaikqmnlqqqpk
keliineilvmrenknpnivnyldsylvgdelwvvmeylaggsltdvvtetcmdegqiaa
vcreclqaleflhsnqvihrniksdnillgmdgsvkltdfgfcaqitpeqskrsemvgtp
ywmapevvtrkaygpkvdiwslgimaiemiegeppylnenplralyliatngtpelqnpe
klsaifrdflnrclemdvekrgsakellqhqflkiakplssltpliaaakeat

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4o0rB (B:)
sdeeileklrsivsvgdpkkkytrfekigqgasgtvytamdvatgqevaikqmnlqqqpk
keliineilvmrenknpnivnyldsylvgdelwvvmeylaggsltdvvtetcmdegqiaa
vcreclqaleflhsnqvihrniksdnillgmdgsvkltdfgfcaqitpeqskrsemvgtp
ywmapevvtrkaygpkvdiwslgimaiemiegeppylnenplralyliatngtpelqnpe
klsaifrdflnrclemdvekrgsakellqhqflkiakplssltpliaaakeatknnhgns

    Sequence, based on observed residues (ATOM records): (download) 
    >4o0rB (B:)
sdeeileklrsivsvgdpkkkytrfekigqgasgtvytamdvatgqevaikqmnlqkeli
ineilvmrenknpnivnyldsylvgdelwvvmeylaggsltdvvtetcmdegqiaavcre
clqaleflhsnqvihrniksdnillgmdgsvkltdfgqskrsemvgtpywmapevvtrka
ygpkvdiwslgimaiemiegeppylnenplralyliatngtpelqnpeklsaifrdflnr
clemdvekrgsakellqhqflkiakplssltpliaaakeatk