PDB entry 4o0e

View 4o0e on RCSB PDB site
Description: Crystal structure of the human L-asparaginase protein T186V mutant
Deposited on 2013-12-13, released 2014-04-30
The last revision was dated 2014-06-18, with a file datestamp of 2014-06-13.
Experiment type: XRAY
Resolution: 1.71 Å
R-factor: 0.175
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Isoaspartyl peptidase/L-asparaginase
    Species: Homo sapiens [TaxId:9606]
    Gene: ASRGL1, ALP, CRASH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7L266 (1-308)
      • expression tag (0)
      • engineered mutation (186)
  • Chain 'B':
    Compound: Isoaspartyl peptidase/L-asparaginase
    Species: Homo sapiens [TaxId:9606]
    Gene: ASRGL1, ALP, CRASH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7L266 (1-308)
      • expression tag (0)
      • engineered mutation (186)
  • Heterogens: NA, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4o0eA (A:)
hmnpivvvhgggagpiskdrkervhqgmvraatvgygilreggsavdavegavvaleddp
efnagcgsvlntngevemdasimdgkdlsagavsavqcianpiklarlvmektphcfltd
qgaaqfaaamgvpeipgeklvternkkrlekekhekgaqktdcqknlgtvgavaldckgn
vayatsvggivnkmvgrvgdspclgaggyadndigavsttghgesilkvnlarltlfhie
qgktveeaadlslgymksrvkglgglivvsktgdwvakwtstsmpwaaakdgklhfgidp
ddttitdlp

    Sequence, based on observed residues (ATOM records):
    >4o0eA (A:)
hmnpivvvhgggagpiskdrkervhqgmvraatvgygilreggsavdavegavvaleddp
efnagcgsvlntngevemdasimdgkdlsagavsavqcianpiklarlvmektphcfltd
qgaaqfaaamgvpeipgeklvternkkrlekekhlgtvgavaldckgnvayatsvggivn
kmvgrvgdspclgaggyadndigavsttghgesilkvnlarltlfhieqgktveeaadls
lgymksrvkglgglivvsktgdwvakwtstsmpwaaakdgklhfgidpddttitdlp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4o0eB (B:)
hmnpivvvhgggagpiskdrkervhqgmvraatvgygilreggsavdavegavvaleddp
efnagcgsvlntngevemdasimdgkdlsagavsavqcianpiklarlvmektphcfltd
qgaaqfaaamgvpeipgeklvternkkrlekekhekgaqktdcqknlgtvgavaldckgn
vayatsvggivnkmvgrvgdspclgaggyadndigavsttghgesilkvnlarltlfhie
qgktveeaadlslgymksrvkglgglivvsktgdwvakwtstsmpwaaakdgklhfgidp
ddttitdlp

    Sequence, based on observed residues (ATOM records):
    >4o0eB (B:)
hmnpivvvhgggagpiskdrkervhqgmvraatvgygilreggsavdavegavvaleddp
efnagcgsvlntngevemdasimdgkdlsagavsavqcianpiklarlvmektphcfltd
qgaaqfaaamgvpeipgeklvternkkrlekekhlgtvgavaldckgnvayatsvggivn
kmvgrvgdspclgaggyadndigavsttghgesilkvnlarltlfhieqgktveeaadls
lgymksrvkglgglivvsktgdwvakwtstsmpwaaakdgklhfgidpddttitdlp