PDB entry 4o0b
View 4o0b on RCSB PDB site
Description: Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease
Class: chaperone/chaperone inhibitor
Keywords: chaperone, CHAPERONE-CHAPERONE INHIBITOR complex
Deposited on
2013-12-13, released
2014-04-09
The last revision prior to the SCOPe 2.07 freeze date was dated
2017-11-22, with a file datestamp of
2017-11-17.
Experiment type: XRAY
Resolution: 1.93 Å
R-factor: N/A
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Heat shock protein HSP 90-alpha
Species: Homo sapiens [TaxId:9606]
Gene: HSP90AA1, HSP90A, HSPC1, HSPCA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d4o0ba_ - Heterogens: 2QA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4o0bA (A:)
gslhmdqpmeeeevetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryes
ltdpskldsgkelhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealq
agadismigqfgvgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrg
tkvilhlkedqteyleerrikeivkkhsqfigypitlfvekerdkevsddeae
Sequence, based on observed residues (ATOM records): (download)
>4o0bA (A:)
evetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryesltdpskldsgke
lhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealqagadismigqfg
vgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrgtkvilhlkedqt
eyleerrikeivkkhsqfigypitlfvek