PDB entry 4o02

View 4o02 on RCSB PDB site
Description: alphavbeta3 integrin in complex with monoclonal antibody fab fragment.
Deposited on 2013-12-13, released 2014-04-02
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-09.
Experiment type: XRAY
Resolution: 3.61 Å
R-factor: N/A
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Integrin alpha-V
    Species: Homo sapiens [TaxId:9606]
    Gene: ITGAV, MSK8, VNRA
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: integrin beta-3
    Species: Homo sapiens [TaxId:9606]
    Gene: ITGB3, GP3A
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: 17E6 heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 4O02 (0-217)
  • Chain 'L':
    Compound: 17E6 light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 4O02 (0-213)
  • Heterogens: NAG, MN, NO3

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4o02A (A:)
fnldvdspaeysgpegsyfgfavdffvpsassrmfllvgapkanttqpgiveggqvlkcd
wsstrrcqpiefdatgnrdyakddplefkshqwfgasvrskqdkilacaplyhwrtemkq
erepvgtcflqdgtktveyapcrsqdidadgqgfcqggfsidftkadrvllggpgsfywq
gqlisdqvaeivskydpnvysikynnqlatrtaqaifddsylgysvavgdfngdgiddfv
sgvpraartlgmvyiydgknmsslynftgeqmaayfgfsvaatdingddyadvfigaplf
mdrgsdgklqevgqvsvslqrasgdfqttklngfevfarfgsaiaplgdldqdgfndiai
aapyggedkkgivyifngrstglnavpsqilegqwaarsmppsfgysmkgatdidkngyp
dlivgafgvdrailyrarpvitvnaglevypsilnqdnktcslpgtalkvscfnvrfclk
adgkgvlprklnfqvellldklkqkgairralflysrspshsknmtisrgglmqceelia
ylrdesefrdkltpitifmeyrldyrtaadttglqpilnqftpanisrqahilldcgedn
vckpklevsvdsdqkkiyigddnpltlivkaqnqgegayeaelivsiplqadfigvvrnn
ealarlscafktenqtrqvvcdlgnpmkagtqllaglrfsvhqqsemdtsvkfdlqiqss
nlfdkvspvvshkvdlavlaaveirgvsspdhvflpipnwehkenpeteedvgpvvqhiy
elrnngpssfskamlhlqwpykynnntllyilhydidgpmnctsdmeinplrikisslqt
tekndtvagqgerdhlitkrdlalsegdihtlgcgvaqclkivcqvgrldrgksailyvk
sllwtetfmnkenqnhsyslkssasfnviefpyknlpieditnstlvttnvtwgiqpapm
pv

    Sequence, based on observed residues (ATOM records):
    >4o02A (A:)
fnldvdspaeysgpegsyfgfavdffvpsassrmfllvgapkanttqpgiveggqvlkcd
wsstrrcqpiefdatgnrdyakddplefkshqwfgasvrskqdkilacaplyhwrtemkq
erepvgtcflqdgtktveyapcrsqdidadgqgfcqggfsidftkadrvllggpgsfywq
gqlisdqvaeivskydpnvysikynnqlatrtaqaifddsylgysvavgdfngdgiddfv
sgvpraartlgmvyiydgknmsslynftgeqmaayfgfsvaatdingddyadvfigaplf
mdrgsdgklqevgqvsvslqrasgdfqttklngfevfarfgsaiaplgdldqdgfndiai
aapyggedkkgivyifngrstglnavpsqilegqwaarsmppsfgysmkgatdidkngyp
dlivgafgvdrailyrarpvitvnaglevypsilnqdnktcslpgtalkvscfnvrfclk
adgkgvlprklnfqvellldklkqkgairralflysrspshsknmtisrgglmqceelia
ylrdesefrdkltpitifmeyrldyrtaadttglqpilnqftpanisrqahilldcgedn
vckpklevsvdsdqkkiyigddnpltlivkaqnqgegayeaelivsiplqadfigvvrnn
ealarlscafktenqtrqvvcdlgnpmkagtqllaglrfsvhqqsemdtsvkfdlqiqss
nlfdkvspvvshkvdlavlaaveirgvsspdhvflpipnwehkenpeteedvgpvvqhiy
elrnngpssfskamlhlqwpykynnntllyilhydidgpmnctsdmeinplrilgcgvaq
clkivcqvgrldrgksailyvksllwtetfmnkenqnhsyslkssasfnviefpyknlpi
editnstlvttnvtw

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4o02B (B:)
gpnicttrgvsscqqclavspmcawcsdealplgsprcdlkenllkdncapesiefpvse
arvledrplsdkgsgdssqvtqvspqrialrlrpddsknfsiqvrqvedypvdiyylmdl
sysmkddlwsiqnlgtklatqmrkltsnlrigfgafvdkpvspymyisppealenpcydm
kttclpmfgykhvltltdqvtrfneevkkqsvsrnrdapeggfdaimqatvcdekigwrn
dashllvfttdakthialdgrlagivqpndgqchvgsdnhysasttmdypslglmtekls
qkninlifavtenvvnlyqnyselipgttvgvlsmdssnvlqlivdaygkirskvelevr
dlpeelslsfnatclnnevipglkscmglkigdtvsfsieakvrgcpqekeksftikpvg
fkdslivqvtfdcdcacqaqaepnshrcnngngtfecgvcrcgpgwlgsqcecseedyrp
sqqdecspregqpvcsqrgeclcgqcvchssdfgkitgkycecddfscvrykgemcsghg
qcscgdclcdsdwtgyycncttrtdtcmssngllcsgrgkcecgscvciqpgsygdtcek
cptcpdactfkkecveckkfdrgalhdentcnrycrdeiesvkelkdtgkdavnctykne
ddcvvrfqyyedssgksilyvveepecpkgpd

    Sequence, based on observed residues (ATOM records):
    >4o02B (B:)
gpnicttrgvsscqqclavspmcawcsdealplgsprcdlkenllkdncapesiefpvse
arvledrplsdkgsgdssqvtqvspqrialrlrpddsknfsiqvrqvedypvdiyylmdl
sysmkddlwsiqnlgtklatqmrkltsnlrigfgafvdkpvspymyisppealenpcydm
kttclpmfgykhvltltdqvtrfneevkkqsvsrnrdapeggfdaimqatvcdekigwrn
dashllvfttdakthialdgrlagivqpndgqchvgsdnhysasttmdypslglmtekls
qkninlifavtenvvnlyqnyselipgttvgvlsmdssnvlqlivdaygkirskvelevr
dlpeelslsfnatclnnevipglkscmglkigdtvsfsieakvrgcpqekeksftikpvg
fkdslivqvtfdcdcacqaqaepnshrcnngngtfecgvcrcgpgwlgsqcecseedyrp
sqqdecspregqpvcsqrgeclcgqcvchssdfgkitgkycecddfscvrykgemcsghg
qcscgdclcdsdwtgyycncttrtdtcmssngllcsgrgkcecgscvciqpgsygdtcek
cptcpdactfkkecveckkfdrgalhdentcnrycrdeiesvkelkdtgkdavnctykne
ddcvvrfqyyedssgksilyvveepec

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records:
    >4o02H (H:)
qvqlqqsgaelaepgasvkmsckasgytfssfwmhwvkqrpgqglewigyinprsgytec
neifrdkatmtadtssstaymqlsgltsedsavyycasflgrgamdywgqgtsvtvssak
ttapsvyplapvcgdttgssvtlgclvkgyfpepvtltwnsgslsagvhtfpavlqsdly
tlsssvtvtsstwpsqsitcnvahpasstkvdkkiepr

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records:
    >4o02L (L:)
diqmtqttsslsaslgdrviiscrasqdisnylswyqqkpdgtvkllifytsklhsgvps
rfsgsgsgtdysltisnldqediatyfcqqgntfpytfgggtkvemrradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec