PDB entry 4nyi
View 4nyi on RCSB PDB site
Description: Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange
Class: signaling protein
Keywords: Ras SOS complex, signal transduction, Raf, PI3K, poly-petide, cytosol, SIGNALING PROTEIN
Deposited on
2013-12-10, released
2014-03-12
The last revision prior to the SCOPe 2.07 freeze date was dated
2014-03-19, with a file datestamp of
2014-03-14.
Experiment type: XRAY
Resolution: 2.96 Å
R-factor: 0.167
AEROSPACI score: 0.23
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'Q':
Compound: gtpase hras
Species: Homo sapiens [TaxId:9606]
Gene: HRAS, HRAS1
Database cross-references and differences (RAF-indexed):
- Uniprot P01112 (1-166)
- expression tag (0)
- engineered mutation (64)
Domains in SCOPe 2.07: d4nyiq1, d4nyiq2 - Chain 'R':
Compound: gtpase hras
Species: Homo sapiens [TaxId:9606]
Gene: HRAS, HRAS1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d4nyir1, d4nyir2 - Chain 'S':
Compound: Son of sevenless homolog 1
Species: Homo sapiens [TaxId:9606]
Gene: SOS1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d4nyis_ - Heterogens: MG, GNP, 2PX, HOH
PDB Chain Sequences:
- Chain 'Q':
Sequence; same for both SEQRES and ATOM records: (download)
>4nyiQ (Q:)
gmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeasamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcd
laartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh
- Chain 'R':
Sequence; same for both SEQRES and ATOM records: (download)
>4nyiR (R:)
gmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcd
laartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh
- Chain 'S':
Sequence, based on SEQRES records: (download)
>4nyiS (S:)
qmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpnfvr
tflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpv
qlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiard
ngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselv
gsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqel
nnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinpp
cvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrves
dikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsnp
r
Sequence, based on observed residues (ATOM records): (download)
>4nyiS (S:)
qmrlpsadvyrfaepdseeniifeenmagipiikagtviklierltyhmyadpnfvrtfl
ttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpvqlr
vlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiahnitf
qsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedk
einspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlev
vsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyl
tnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenl
npmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsnpr