PDB entry 4nyi

View 4nyi on RCSB PDB site
Description: Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange
Class: signaling protein
Keywords: Ras SOS complex, signal transduction, Raf, PI3K, poly-petide, cytosol, SIGNALING PROTEIN
Deposited on 2013-12-10, released 2014-03-12
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-03-19, with a file datestamp of 2014-03-14.
Experiment type: XRAY
Resolution: 2.96 Å
R-factor: 0.167
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'Q':
    Compound: gtpase hras
    Species: Homo sapiens [TaxId:9606]
    Gene: HRAS, HRAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01112 (1-166)
      • expression tag (0)
      • engineered mutation (64)
    Domains in SCOPe 2.05: d4nyiq_
  • Chain 'R':
    Compound: gtpase hras
    Species: Homo sapiens [TaxId:9606]
    Gene: HRAS, HRAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01112 (1-166)
      • expression tag (0)
    Domains in SCOPe 2.05: d4nyir_
  • Chain 'S':
    Compound: Son of sevenless homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SOS1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4nyis_
  • Heterogens: MG, GNP, 2PX, HOH

PDB Chain Sequences:

  • Chain 'Q':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4nyiQ (Q:)
gmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeasamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcd
laartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

  • Chain 'R':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4nyiR (R:)
gmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcd
laartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

  • Chain 'S':
    Sequence, based on SEQRES records: (download) 
    >4nyiS (S:)
qmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpnfvr
tflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpv
qlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiard
ngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselv
gsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqel
nnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinpp
cvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrves
dikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsnp
r

    Sequence, based on observed residues (ATOM records): (download) 
    >4nyiS (S:)
qmrlpsadvyrfaepdseeniifeenmagipiikagtviklierltyhmyadpnfvrtfl
ttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpvqlr
vlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiahnitf
qsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedk
einspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlev
vsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyl
tnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenl
npmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsnpr