PDB entry 4nwg
View 4nwg on RCSB PDB site
Description: Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation
Class: Hydrolase
Keywords: Hydrolase
Deposited on
2013-12-06, released
2014-12-10
The last revision prior to the SCOPe 2.04 freeze date was dated
2014-12-10, with a file datestamp of
2014-12-05.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: 0.281
AEROSPACI score: 0.18
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Tyrosine-protein phosphatase non-receptor type 11
Species: Homo sapiens [TaxId:9606]
Gene: PTPN11, PTP2C, SHPTP2
Database cross-references and differences (RAF-indexed):
- Uniprot Q06124
- engineered mutation (138)
Domains in SCOPe 2.04: d4nwga1, d4nwga2, d4nwga3 - Chain 'B':
Compound: Tyrosine-protein phosphatase non-receptor type 11
Species: Homo sapiens [TaxId:9606]
Gene: PTPN11, PTP2C, SHPTP2
Database cross-references and differences (RAF-indexed):
- Uniprot Q06124
- engineered mutation (138)
- Heterogens: EDO, PEG, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4nwgA (A:)
mtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntg
dyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsgk
eaeklltekgkhgsflvrdsqshpgdfvlsvrtgddkgesndgkskvthvmircqelkyd
vgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaett
dkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpnep
vsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttkev
ergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhf
rtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiir
ekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietlqrrieeeqkskrkg
Sequence, based on observed residues (ATOM records): (download)
>4nwgA (A:)
tsrrwfhpnitgveaenllltrgvdgsflarpsnpgdftlsvrrngavthikiqntgdyy
dlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsgaekl
ltekgkhgsflvrdsqshpgdfvlsvrtgdskvthvmircqelkydvgggerfdsltdlv
ehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsgfweefetlqqqeckllysr
kegqrqenknknryknilpfdhtrvvlhdgdpnpvsdyinaniimpekksyiatqgclqn
tvndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdy
tlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvv
vhcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiym
avqhyietlqrrieeeqk
- Chain 'B':
No sequence available.