PDB entry 4nwg

View 4nwg on RCSB PDB site
Description: Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation
Class: Hydrolase
Keywords: Hydrolase
Deposited on 2013-12-06, released 2014-12-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-12-10, with a file datestamp of 2014-12-05.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: 0.281
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124
      • engineered mutation (138)
    Domains in SCOPe 2.08: d4nwga1, d4nwga2, d4nwga3
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124
      • engineered mutation (138)
    Domains in SCOPe 2.08: d4nwgb1, d4nwgb2, d4nwgb3
  • Heterogens: EDO, PEG, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4nwgA (A:)
mtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntg
dyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsgk
eaeklltekgkhgsflvrdsqshpgdfvlsvrtgddkgesndgkskvthvmircqelkyd
vgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaett
dkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpnep
vsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttkev
ergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhf
rtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiir
ekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietlqrrieeeqkskrkg

    Sequence, based on observed residues (ATOM records): (download) 
    >4nwgA (A:)
tsrrwfhpnitgveaenllltrgvdgsflarpsnpgdftlsvrrngavthikiqntgdyy
dlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsgaekl
ltekgkhgsflvrdsqshpgdfvlsvrtgdskvthvmircqelkydvgggerfdsltdlv
ehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsgfweefetlqqqeckllysr
kegqrqenknknryknilpfdhtrvvlhdgdpnpvsdyinaniimpekksyiatqgclqn
tvndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdy
tlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvv
vhcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiym
avqhyietlqrrieeeqk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4nwgB (B:)
mtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntg
dyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsgk
eaeklltekgkhgsflvrdsqshpgdfvlsvrtgddkgesndgkskvthvmircqelkyd
vgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaett
dkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpnep
vsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttkev
ergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhf
rtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiir
ekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietlqrrieeeqkskrkg

    Sequence, based on observed residues (ATOM records): (download) 
    >4nwgB (B:)
tsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgd
yydlygekfatlaelvqyymehhgqlvielkyplncadptserwfhghlsgeaeklltek
gkhgsflvrdsqshpgdfvlsvrtgdskvthvmircqelkydvgggerfdsltdlvehyk
knpmvetlgtvlqlkqplnttrinaaeiesrvrelsgfweefetlqqqeckllysrkegq
rqenknknryknilpfdhtrvvlhdgdpnpvsdyinaniimpeksyiatqgclqntvndf
wrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrel
klskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsa
gigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhy
ietlqrrieeeq