PDB entry 4nue

View 4nue on RCSB PDB site
Description: Crystal structure of the first bromodomain of human BRD4 in complex with MS267 inhibitor
Class: transcription/transcription inhibitor
Keywords: transcription factor, transcription, TRANSCRIPTION-TRANSCRIPTION INHIBITOR complex
Deposited on 2013-12-03, released 2014-04-02
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-04-02, with a file datestamp of 2014-03-28.
Experiment type: XRAY
Resolution: 1.3 Å
R-factor: 0.14
AEROSPACI score: 0.7 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (2-End)
      • expression tag (0-1)
    Domains in SCOPe 2.05: d4nuea_
  • Heterogens: NUE, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4nueA (A:)
    smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
    ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
    nelptee
    

    Sequence, based on observed residues (ATOM records): (download)
    >4nueA (A:)
    smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
    ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
    nelpte