PDB entry 4nst

View 4nst on RCSB PDB site
Description: Crystal structure of human Cdk12/Cyclin K in complex with ADP-aluminum fluoride
Class: transferase/transcription
Keywords: transcription, RNA polymerase II, phosphorylation, TRANSFERASE-TRANSCRIPTION complex
Deposited on 2013-11-29, released 2014-03-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-10-01, with a file datestamp of 2014-09-26.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.198
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 12
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK12, CRK7, CRKRS, KIAA0904
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4nsta_
  • Chain 'B':
    Compound: cyclin-k
    Species: Homo sapiens [TaxId:9606]
    Gene: CCNK, CPR4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4nstb1, d4nstb2
  • Chain 'C':
    Compound: cyclin-dependent kinase 12
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK12, CRK7, CRKRS, KIAA0904
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4nstc_
  • Chain 'D':
    Compound: cyclin-k
    Species: Homo sapiens [TaxId:9606]
    Gene: CCNK, CPR4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4nstd1, d4nstd2
  • Heterogens: ADP, AF3, MG, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4nstA (A:)
gqtesdwgkrcvdkfdiigiigegtygqvykakdkdtgelvalkkvrldnekegfpitai
reikilrqlihrsvvnmkeivtdkqdaldfkkdkgafylvfeymdhdlmgllesglvhfs
edhiksfmkqlmegleychkknflhrdikcsnillnnsgqikladfglarlynseesrpy
tnkvitlwyrppelllgeerytpaidvwscgcilgelftkkpifqanlelaqlelisrlc
gspcpavwpdviklpyfntmkpkkqyrrrlreefsfipsaaldlldhmltldpskrctae
qtlqsdflkdvelskmappdlphwqdchelwskkrrrqrqsgvvveeppps

    Sequence, based on observed residues (ATOM records): (download) 
    >4nstA (A:)
esdwgkrcvdkfdiigiigegtygqvykakdkdtgelvalkkvrldnekegfpitairei
kilrqlihrsvvnmkeivtdkqdgafylvfeymdhdlmgllesglvhfsedhiksfmkql
megleychkknflhrdikcsnillnnsgqikladfglarlynseesrpytnkvitlwyrp
pelllgeerytpaidvwscgcilgelftkkpifqanlelaqlelisrlcgspcpavwpdv
iklpyfntmkpkkqyrrrlreefsfipsaaldlldhmltldpskrctaeqtlqsdflkdv
elskmappdlphwqdchelwskk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4nstB (B:)
gmkenkensspsvtsanldhtkpcwywdkkdlahtpsqlegldpatearyrregarfifd
vgtrlglhydtlatgiiyfhrfymfhsfkqfpryvtgacclflagkveetpkkckdiikt
arsllndvqfgqfgddpkeevmvlerillqtikfdlqvehpyqfllkyakqlkgdknkiq
klvqmawtfvndslcttlslqwepeiiavavmylagrlckfeiqewtskpmyrrwweqfv
qdvpvdvledichqildlysqgkqqmph

    Sequence, based on observed residues (ATOM records): (download) 
    >4nstB (B:)
tkpcwywdkkdlahtpsqlegldpatearyrregarfifdvgtrlglhydtlatgiiyfh
rfymfhsfkqfpryvtgacclflagkveetpkkckdiiktarsllndvqfgqfgddpkee
vmvlerillqtikfdlqvehpyqfllkyakqlkgdknkiqklvqmawtfvndslcttlsl
qwepeiiavavmylagrlckfeiqewtskpmyrrwweqfvqdvpvdvledichqildlys
qgkqqm

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4nstC (C:)
gqtesdwgkrcvdkfdiigiigegtygqvykakdkdtgelvalkkvrldnekegfpitai
reikilrqlihrsvvnmkeivtdkqdaldfkkdkgafylvfeymdhdlmgllesglvhfs
edhiksfmkqlmegleychkknflhrdikcsnillnnsgqikladfglarlynseesrpy
tnkvitlwyrppelllgeerytpaidvwscgcilgelftkkpifqanlelaqlelisrlc
gspcpavwpdviklpyfntmkpkkqyrrrlreefsfipsaaldlldhmltldpskrctae
qtlqsdflkdvelskmappdlphwqdchelwskkrrrqrqsgvvveeppps

    Sequence, based on observed residues (ATOM records): (download) 
    >4nstC (C:)
sdwgkrcvdkfdiigiigegtygqvykakdkdtgelvalkkvrldnekegfpitaireik
ilrqlihrsvvnmkeivtdkgafylvfeymdhdlmgllesglvhfsedhiksfmkqlmeg
leychkknflhrdikcsnillnnsgqikladfglarlynsesrpytnkvitlwyrppell
lgeerytpaidvwscgcilgelftkkpifqanlelaqlelisrlcgspcpavwpdviklp
yfntmkpkkqyrrrlreefsfipsaaldlldhmltldpskrctaeqtlqsdflkdvelsk
mappdlphwqdchelwsk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4nstD (D:)
gmkenkensspsvtsanldhtkpcwywdkkdlahtpsqlegldpatearyrregarfifd
vgtrlglhydtlatgiiyfhrfymfhsfkqfpryvtgacclflagkveetpkkckdiikt
arsllndvqfgqfgddpkeevmvlerillqtikfdlqvehpyqfllkyakqlkgdknkiq
klvqmawtfvndslcttlslqwepeiiavavmylagrlckfeiqewtskpmyrrwweqfv
qdvpvdvledichqildlysqgkqqmph

    Sequence, based on observed residues (ATOM records): (download) 
    >4nstD (D:)
kpcwywdkkdlahtpsqlegldpatearyrregarfifdvgtrlglhydtlatgiiyfhr
fymfhsfkqfpryvtgacclflagkveetpkkckdiiktarsllndvqfgqfgddpkeev
mvlerillqtikfdlqvehpyqfllkyakqlkgdknkiqklvqmawtfvndslcttlslq
wepeiiavavmylagrlckfeiqewtskpmyrrwweqfvqdvpvdvledichqildlysq
g