PDB entry 4npu

View 4npu on RCSB PDB site
Description: Crystal Structure of HIV-1 Protease Multiple Mutant P51
Class: hydrolase
Keywords: HIV-1 protease, P51, multiple mutant, drug resistance, Hydrolase
Deposited on 2013-11-22, released 2014-10-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-10-08, with a file datestamp of 2014-10-03.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: 0.161
AEROSPACI score: 0.58 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot O38896
    • engineered mutation (6)
    • engineered mutation (24)
    • engineered mutation (31-32)
    • engineered mutation (36)
    • engineered mutation (53)
    • engineered mutation (66)
    • engineered mutation (81)
    • engineered mutation (83)
    • engineered mutation (94)
  Domains in SCOPe 2.08: d4npua_
• Chain 'B':
  Compound: Protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot O38896 (0-98)
    • engineered mutation (6)
    • engineered mutation (24)
    • engineered mutation (31-32)
    • engineered mutation (36)
    • engineered mutation (53)
    • engineered mutation (66)
    • engineered mutation (81)
    • engineered mutation (83)
    • engineered mutation (94)
  Domains in SCOPe 2.08: d4npub_
• Heterogens: HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4npuA (A:)
  pqitlwkrpivtikvggqlrealintgaddtifeeislpgrwkpkliggiggfmkvrqyd
  qipieiaghqaigtvlvgptpinvigrnmltqigatlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4npuB (B:)
  pqitlwkrpivtikvggqlrealintgaddtifeeislpgrwkpkliggiggfmkvrqyd
  qipieiaghqaigtvlvgptpinvigrnmltqigatlnf