PDB entry 4nnd

View 4nnd on RCSB PDB site
Description: Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites
Deposited on 2013-11-17, released 2014-11-19
The last revision was dated 2014-11-19, with a file datestamp of 2014-11-14.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.264
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 18
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN18, BDP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99952 (0-End)
      • engineered mutation (223)
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 18
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN18, BDP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99952 (0-End)
      • engineered mutation (223)
  • Chain 'C':
    Compound: Receptor tyrosine-protein kinase erbB-2
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Tyrosine-protein phosphatase non-receptor type 18
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN18, BDP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99952 (0-End)
      • engineered mutation (223)
  • Chain 'E':
    Compound: Receptor tyrosine-protein kinase erbB-2
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Receptor tyrosine-protein kinase erbB-2
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Tyrosine-protein phosphatase non-receptor type 18
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN18, BDP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99952 (0-End)
      • engineered mutation (223)
  • Chain 'H':
    Compound: Receptor tyrosine-protein kinase erbB-2
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4nndA (A:)
dsarsflerlearggregavlagefsdiqacsaawkadgvcstvagsrpenvrknrykdv
lpydqtrvilsllqeeghsdyingnfirgvdgslayiatqgplphtlldfwrlvwefgvk
vilmacreiengrkrcerywaqeqeplqtglfcitlikekwlnedimlrtlkvtfqkesr
svyqlqymswpdrgvpsspdhmlamveearrlqgsgpeplcvhssagcgrtgvlctvdyv
rqllltqmippdfslfdvvlkmrkqrpaavqteeqyrflyhtvaqmfcst

    Sequence, based on observed residues (ATOM records):
    >4nndA (A:)
dsarsflerlearavlagefsdiqacsaawkadgvcstvagsrpenvrknrykdvlpydq
trvilsllqeeghsdyingnfirgvdgslayiatqgplphtlldfwrlvwefgvkvilma
creiengrkrcerywaqeqeplqtglfcitlikekwlnedimlrtlkvtfqkesrsvyql
qymswpdrgvpsspdhmlamveearrlqgsgpeplcvhssagcgrtgvlctvdyvrqlll
tmippdfslfdvvlkmrkqrpaavqteeqyrflyhtvaqmfcs

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4nndB (B:)
dsarsflerlearggregavlagefsdiqacsaawkadgvcstvagsrpenvrknrykdv
lpydqtrvilsllqeeghsdyingnfirgvdgslayiatqgplphtlldfwrlvwefgvk
vilmacreiengrkrcerywaqeqeplqtglfcitlikekwlnedimlrtlkvtfqkesr
svyqlqymswpdrgvpsspdhmlamveearrlqgsgpeplcvhssagcgrtgvlctvdyv
rqllltqmippdfslfdvvlkmrkqrpaavqteeqyrflyhtvaqmfcst

    Sequence, based on observed residues (ATOM records):
    >4nndB (B:)
dsarsflerlearvlagefsdiqacsaawkadgvcstvagsrpenvrknrykdvlpydqt
rvilsllqeeghsdyingnfirgvdgslayiatqgplphtlldfwrlvwefgvkvilmac
reiengrkrcerywaqeqeplqtglfcitlikekwlnedimlrtlkvtfqkesrsvyqlq
ymswpdrgvpsspdhmlamveearrlqgsgpeplcvhssagcgrtgvlctvdyvrqlllt
qmippdfslfdvvlkmrkqrpaavqteeqyrflyhtvaqmfcs

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >4nndC (C:)
lqryse

  • Chain 'D':
    Sequence, based on SEQRES records:
    >4nndD (D:)
dsarsflerlearggregavlagefsdiqacsaawkadgvcstvagsrpenvrknrykdv
lpydqtrvilsllqeeghsdyingnfirgvdgslayiatqgplphtlldfwrlvwefgvk
vilmacreiengrkrcerywaqeqeplqtglfcitlikekwlnedimlrtlkvtfqkesr
svyqlqymswpdrgvpsspdhmlamveearrlqgsgpeplcvhssagcgrtgvlctvdyv
rqllltqmippdfslfdvvlkmrkqrpaavqteeqyrflyhtvaqmfcst

    Sequence, based on observed residues (ATOM records):
    >4nndD (D:)
dsarsflerleavlagefsdiqacsaawkadgvcstvagsrpenvrknrykdvlpydqtr
vilsllqeehsdyingnfirgvdgslayiatqgplphtlldfwrlvwefgvkvilmacre
iengrkrcerywaqeqeplqtglfcitlikekwlnedimlrtlkvtfqkesrsvyqlqym
swpdrgvpsspdhmlamveearrlqgsgpeplcvhssagcgrtgvlctvdyvrqllltqm
ippdfslfdvvlkmrkqrpaavqteeqyrflyhtvaqmfcs

  • Chain 'E':
    Sequence, based on SEQRES records:
    >4nndE (E:)
lqryse

    Sequence, based on observed residues (ATOM records):
    >4nndE (E:)
lqrys

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records:
    >4nndF (F:)
lqryse

  • Chain 'G':
    Sequence, based on SEQRES records:
    >4nndG (G:)
dsarsflerlearggregavlagefsdiqacsaawkadgvcstvagsrpenvrknrykdv
lpydqtrvilsllqeeghsdyingnfirgvdgslayiatqgplphtlldfwrlvwefgvk
vilmacreiengrkrcerywaqeqeplqtglfcitlikekwlnedimlrtlkvtfqkesr
svyqlqymswpdrgvpsspdhmlamveearrlqgsgpeplcvhssagcgrtgvlctvdyv
rqllltqmippdfslfdvvlkmrkqrpaavqteeqyrflyhtvaqmfcst

    Sequence, based on observed residues (ATOM records):
    >4nndG (G:)
dsarsflerlvlagefsdiqacsaawkadgvcstvagsrpenvrknrykdvlpydqtrvi
lsllqeehsdyingnfirgvdgslayiatqgplphtlldfwrlvwefgvkvilmacreie
ngrkrcerywaqeqeplqtglfcitlikekwlnedimlrtlkvtfqkesrsvyqlqymsw
pdrgvpspdhmlamveearrlqgsgpeplcvhssagcgrtgvlctvdyvrqllltqmipp
dfslfdvvlkmrkqrpaavqteeqyrflyhtvaqmfcs

  • Chain 'H':
    Sequence, based on SEQRES records:
    >4nndH (H:)
lqryse

    Sequence, based on observed residues (ATOM records):
    >4nndH (H:)
lqrys