PDB entry 4nmm
View 4nmm on RCSB PDB site
Description: Crystal Structure of a G12C Oncogenic Variant of Human KRas Bound to a Novel GDP Competitive Covalent Inhibitor
Class: hydrolase/hydrolase inhibitor
Keywords: Small GTPase, GDP bound, oncogenic mutation, covalent inhibitor, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on
2013-11-15, released
2014-06-04
The last revision prior to the SCOPe 2.06 freeze date was dated
2014-07-09, with a file datestamp of
2014-07-03.
Experiment type: XRAY
Resolution: 1.89 Å
R-factor: 0.186
AEROSPACI score: 0.41
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: GTPase KRas
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116 (1-169)
- expression tag (0)
- engineered mutation (12)
Domains in SCOPe 2.06: d4nmma1, d4nmma2 - Heterogens: MG, Y9Z, HOH