PDB entry 4nmk

View 4nmk on RCSB PDB site
Description: Thermostable aldehyde dehydrogenase from Pyrobaculum sp. crystallized in microgravity (complex with NADP+)
Class: oxidoreductase
Keywords: aldehyde oxidation, NADP reduction, intracellular, OXIDOREDUCTASE
Deposited on 2013-11-15, released 2014-11-19
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-11-19, with a file datestamp of 2014-11-14.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.191
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: aldehyde dehydrogenase
    Species: Pyrobaculum sp. 1860 [TaxId:1104324]
    Gene: P186_1147
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4nmka_
  • Chain 'B':
    Compound: aldehyde dehydrogenase
    Species: Pyrobaculum sp. 1860 [TaxId:1104324]
    Gene: P186_1147
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4nmkb_
  • Chain 'C':
    Compound: aldehyde dehydrogenase
    Species: Pyrobaculum sp. 1860 [TaxId:1104324]
    Gene: P186_1147
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4nmkc_
  • Chain 'D':
    Compound: aldehyde dehydrogenase
    Species: Pyrobaculum sp. 1860 [TaxId:1104324]
    Gene: P186_1147
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4nmkd_
  • Chain 'E':
    Compound: aldehyde dehydrogenase
    Species: Pyrobaculum sp. 1860 [TaxId:1104324]
    Gene: P186_1147
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4nmke_
  • Chain 'F':
    Compound: aldehyde dehydrogenase
    Species: Pyrobaculum sp. 1860 [TaxId:1104324]
    Gene: P186_1147
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4nmkf_
  • Chain 'G':
    Compound: aldehyde dehydrogenase
    Species: Pyrobaculum sp. 1860 [TaxId:1104324]
    Gene: P186_1147
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4nmkg_
  • Chain 'H':
    Compound: aldehyde dehydrogenase
    Species: Pyrobaculum sp. 1860 [TaxId:1104324]
    Gene: P186_1147
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4nmkh_
  • Heterogens: NAP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4nmkA (A:)
midlnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealk
awanipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaael
arhyqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpa
sdtpvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreia
akaagtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkava
dkfieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrsw
gnffepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvn
rafriaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlr
trrfpipsalk

    Sequence, based on observed residues (ATOM records): (download) 
    >4nmkA (A:)
lnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealkawa
nipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaaelarh
yqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpasdt
pvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreiaaka
agtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkavadkf
ieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrswgnf
fepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvnraf
riaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlrtrr
fpipsalk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4nmkB (B:)
midlnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealk
awanipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaael
arhyqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpa
sdtpvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreia
akaagtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkava
dkfieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrsw
gnffepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvn
rafriaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlr
trrfpipsalk

    Sequence, based on observed residues (ATOM records): (download) 
    >4nmkB (B:)
mkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealkawanip
airraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaaelarhyqg
rvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpasdtpvt
gwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreiaakaagt
lktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkavadkfier
yvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrswgnffep
aifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvnrafria
eavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlrtrrfpi
psal

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4nmkC (C:)
midlnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealk
awanipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaael
arhyqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpa
sdtpvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreia
akaagtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkava
dkfieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrsw
gnffepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvn
rafriaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlr
trrfpipsalk

    Sequence, based on observed residues (ATOM records): (download) 
    >4nmkC (C:)
idlnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealka
wanipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaaela
rhyqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpas
dtpvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreiaa
kaagtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkavad
kfieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrswg
nffepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvnr
afriaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlrt
rrfpipsalk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4nmkD (D:)
midlnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealk
awanipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaael
arhyqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpa
sdtpvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreia
akaagtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkava
dkfieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrsw
gnffepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvn
rafriaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlr
trrfpipsalk

    Sequence, based on observed residues (ATOM records): (download) 
    >4nmkD (D:)
mkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealkawanip
airraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaaelarhyqg
rvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpasdtpvt
gwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreiaakaagt
lktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkavadkfier
yvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrswgnffep
aifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvnrafria
eavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlrtrrfpi
psalk

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4nmkE (E:)
midlnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealk
awanipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaael
arhyqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpa
sdtpvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreia
akaagtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkava
dkfieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrsw
gnffepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvn
rafriaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlr
trrfpipsalk

    Sequence, based on observed residues (ATOM records): (download) 
    >4nmkE (E:)
mkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealkawanip
airraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaaelarhyqg
rvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpasdtpvt
gwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreiaakaagt
lktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkavadkfier
yvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrswgnffep
aifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvnrafria
eavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlrtrrfpi
psalk

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4nmkF (F:)
midlnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealk
awanipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaael
arhyqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpa
sdtpvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreia
akaagtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkava
dkfieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrsw
gnffepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvn
rafriaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlr
trrfpipsalk

    Sequence, based on observed residues (ATOM records): (download) 
    >4nmkF (F:)
idlnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealka
wanipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaaela
rhyqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpas
dtpvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreiaa
kaagtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkavad
kfieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrswg
nffepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvnr
afriaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlrt
rrfpipsalk

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4nmkG (G:)
midlnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealk
awanipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaael
arhyqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpa
sdtpvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreia
akaagtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkava
dkfieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrsw
gnffepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvn
rafriaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlr
trrfpipsalk

    Sequence, based on observed residues (ATOM records): (download) 
    >4nmkG (G:)
mkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealkawanip
airraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaaelarhyqg
rvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpasdtpvt
gwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreiaakaagt
lktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkavadkfier
yvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrswgnffep
aifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvnrafria
eavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlrtrrfpi
psal

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4nmkH (H:)
midlnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealk
awanipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaael
arhyqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpa
sdtpvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreia
akaagtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkava
dkfieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrsw
gnffepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvn
rafriaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlr
trrfpipsalk

    Sequence, based on observed residues (ATOM records): (download) 
    >4nmkH (H:)
lnimkvanyingefkepstgafqvktspvdgskiaevprsgredareaidsafealkawa
nipairraeylykmlevfrqmkedfmkiltvegggtyrkvwgevvfterliqnaaelarh
yqgrvlqsdsestisvvfkrskgvvgvitpwnyplsismkkiahtlavgntvvykpasdt
pvtgwliaqmvakaglpkgvfnlvigpgpvvgeeivthkrvahvtftgesstgreiaaka
agtlktvtlelggsdpliilddvdvdyaarlavfaslfhqgqictsakriivhkavadkf
ieryvhyvkmlriddprkdekvdlgplinerqvalmkefvddavsrggrlliggrswgnf
fepaifvdvdrnfrimreevfgpvrpivvvenddqavevandtdyglsgavltnnvnraf
riaeavesgmfhindvtfleeshvpfggikasgvgreggewsfhettydrwvtvtlrtrr
fpipsalk